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Literature summary extracted from

  • Castillo, S.S.; Levy, M.; Thaikoottathil, J.V.; Goldkorn, T.
    Reactive nitrogen and oxygen species activate different sphingomyelinases to induce apoptosis in airway epithelial cells (2007), Exp. Cell Res., 313, 2680-2686.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.12 H2O2 reactive oxygen species, e.g. hydrogen peroxide, specifically activate neutral sphingomyelinase 2 to generate ceramide and induce apoptosis in airway epithelial cells, overview Homo sapiens
3.1.4.12 ONOO- peroxynitrite specifically activates the acidic sphingomyelinase Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.12 additional information siRNA knockdown of both nSMase2 and aSMase, silencing nSMase2 prevents H2O2-induced apoptosis, but has no effect on ONOO--induced apoptosis, while silencing of aSMase markedly impairs ONOO--induced apoptosis, but does not affect H2O2-induced apoptosis Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 additional information Homo sapiens reactive oxygen species, e.g. hydrogen peroxide, specifically activate neutral sphingomyelinase 2 to generate ceramide and induce apoptosis in airway epithelial cells, different oxidants modulate different enzymes of the ceramide generating machinery to induce apoptosis in airway epithelial cells, overview ?
-
?
3.1.4.12 sphingomyelin + H2O Homo sapiens
-
N-acylsphingosine + choline phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 epithelial cell airway Homo sapiens
-
3.1.4.12 HAE cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 additional information reactive oxygen species, e.g. hydrogen peroxide, specifically activate neutral sphingomyelinase 2 to generate ceramide and induce apoptosis in airway epithelial cells, different oxidants modulate different enzymes of the ceramide generating machinery to induce apoptosis in airway epithelial cells, overview Homo sapiens ?
-
?
3.1.4.12 sphingomyelin + H2O
-
Homo sapiens N-acylsphingosine + choline phosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 acidic sphingomyelinase
-
Homo sapiens
3.1.4.12 aSMase
-
Homo sapiens
3.1.4.12 neutral sphingomyelinase 2
-
Homo sapiens
3.1.4.12 nSMase2
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.4.12 37
-
assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.12 4.5
-
acidic SMase Homo sapiens
3.1.4.12 7.4
-
neutral SMase Homo sapiens