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Literature summary extracted from

  • Hashimoto, A.; Yoshikawa, M.; Andoh, H.; Yano, H.; Matsumoto, H.; Kawaguchi, M.; Oka, T.; Kobayashi, H.
    Effects of MK-801 on the expression of serine racemase and D-amino acid oxidase mRNAs and on the D-serine levels in rat brain (2007), Eur. J. Pharmacol., 555, 17-22.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.4.3.3 (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine MK-801, a dose-dependent elevation in the expression of DAO mRNA is observed in most brain areas 4 h after the administration (1.6 mg/kg) Rattus norvegicus
5.1.1.18 additional information non-competitive N-methyl-D-aspartate receptor antagonist MK-801 causes an increase of serine racemase and D-serine levels in almost all brain areas, e.g. in striatum, hippocampus, cortex, diencephalon, midbrain, pons-medulla, and cerebellum, overview Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.3 (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine MK-801, a drastic decline in the expression of DAO mRNA is observed in most brain areas 1 h after the MK-801 administration (1.6 mg/kg) Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.1.1.18 L-serine Rattus norvegicus
-
 D-serine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.3 Rattus norvegicus
-
-
-
5.1.1.18 Rattus norvegicus
-
 maleWistar rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.3 brain
-
 Rattus norvegicus
-
5.1.1.18 brain
-
 Rattus norvegicus
-
5.1.1.18 brain cortex
-
 Rattus norvegicus
-
5.1.1.18 cerebellum
-
 Rattus norvegicus
-
5.1.1.18 diencephalon
-
 Rattus norvegicus
-
5.1.1.18 hippocampus
-
 Rattus norvegicus
-
5.1.1.18 midbrain
-
 Rattus norvegicus
-
5.1.1.18 pons
-
 Rattus norvegicus
-
5.1.1.18 striatum
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
5.1.1.18 additional information
-
 D-serine concentration in brain areas, overview Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.3 D-serine + H2O + O2
-
 Rattus norvegicus 2-oxo-3-hydroxypropionic acid + NH3 + H2O2
-
 ?
5.1.1.18 L-serine
-
 Rattus norvegicus D-serine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.3 D-amino acid oxidase
-
 Rattus norvegicus
1.4.3.3 DAO
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.3 FAD
-
 Rattus norvegicus