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Literature summary extracted from

  • Verrall, L.; Walker, M.; Rawlings, N.; Benzel, I.; Kew, J.N.; Harrison, P.J.; Burnet, P.W.
    D-Amino acid oxidase and serine racemase in human brain: normal distribution and altered expression in schizophrenia (2007), Eur. J. Neurosci., 26, 1657-1669.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.1.1.18 L-serine Homo sapiens D-serine is an N-methyl-d-aspartate receptor co-agonist, synthesized by serine racemase and degraded by d-amino acid oxidase D-serine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.3 Homo sapiens
-
-
-
5.1.1.18 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.3 brain cortex dorsolateral prefrontal cortex Homo sapiens
-
1.4.3.3 cerebellum
-
 Homo sapiens
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1.4.3.3 hippocampus
-
 Homo sapiens
-
1.4.3.3 pars compacta
-
 Homo sapiens
-
1.4.3.3 Purkinje cell
-
 Homo sapiens
-
5.1.1.18 brain cerebellum and dorsolateral prefrontal cortex, the enzyme is principally glial in all regions, but shows altered expression in schizophrenia increasing in the dorsolateral prefrontal cortex but not in cerebellum, expression analysis in healthy and schizophrenic brains, overview, no expression in Substantia nigra or in dentate gyrus granule cells or pyramidal neurons of the hippocampus and the dorsolateral prefrontal cortex, no expression in granule cells and Golgi cells of he cerebellum Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.3 D-serine + H2O + O2
-
 Homo sapiens 2-oxo-3-hydroxypropionic acid + NH3 + H2O2
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 ?
5.1.1.18 L-serine
-
 Homo sapiens D-serine
-
 ?
5.1.1.18 L-serine D-serine is an N-methyl-d-aspartate receptor co-agonist, synthesized by serine racemase and degraded by d-amino acid oxidase Homo sapiens D-serine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.3 D-amino acid oxidase
-
 Homo sapiens
1.4.3.3 DAAO
-
 Homo sapiens
5.1.1.18 SRR
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.3 FAD
-
 Homo sapiens