Any feedback?
Literature summary extracted from
- ADAMTS-5: the story so far (2008), Eur. Cell Mater., 15, 11-26.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.B12 | interleukin-1alpha | increased transcription in the presence of interleukin-1alpha | Mus musculus | |
| 3.4.24.B12 | interleukin-1alpha | increased transcription in the presence of interleukin-1alpha | Homo sapiens | |
| 3.4.24.B12 | interleukin-1alpha | increased transcription in the presence of interleukin-1alpha | Bos taurus | |
| 3.4.24.B12 | interleukin-1beta | increased transcription in the presence of interleukin-1beta | Bos taurus | |
| 3.4.24.B12 | oncostatin M | increased transcription in the presence of interleukin-1alpha | Homo sapiens | |
| 3.4.24.B12 | retinoate | increased transcription in the presence of retinoate | Mus musculus |  |
| 3.4.24.B12 | tissue necrosis factor alpha | increased transcription in the presence of tissue necrosis factor alpha | Bos taurus |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.24.B12 | expressed in CHO cells | Mus musculus |
| 3.4.24.B12 | expressed in HTB-94 human chondrosarcoma cell line | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.B12 | alpha2-Macroglobulin | - |
Bos taurus | |
| 3.4.24.B12 | alpha2-Macroglobulin | - |
Homo sapiens | |
| 3.4.24.B12 | alpha2-Macroglobulin | - |
Mus musculus | |
| 3.4.24.B12 | additional information | TIMP-1, TIMP-2 and TIMP-4 do not inhibit ADAMTS-5 | Bos taurus | |
| 3.4.24.B12 | additional information | TIMP-1, TIMP-2 and TIMP-4 do not inhibit ADAMTS-5 | Homo sapiens | |
| 3.4.24.B12 | additional information | TIMP-1, TIMP-2 and TIMP-4 do not inhibit ADAMTS-5 | Mus musculus | |
| 3.4.24.B12 | TIMP-3 | potent inhibitor | Bos taurus | |
| 3.4.24.B12 | TIMP-3 | potent inhibitor | Homo sapiens | |
| 3.4.24.B12 | TIMP-3 | potent inhibitor | Mus musculus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.24.B12 | cell surface | - |
Homo sapiens | 9986 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.B12 | Bos taurus | - |
- |
- |
| 3.4.24.B12 | Homo sapiens | - |
- |
- |
| 3.4.24.B12 | Mus musculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.24.B12 | cartilage | - |
Mus musculus | - |
| 3.4.24.B12 | cartilage | - |
Homo sapiens | - |
| 3.4.24.B12 | cartilage | - |
Bos taurus | - |
| 3.4.24.B12 | chondrocyte | - |
Mus musculus | - |
| 3.4.24.B12 | chondrocyte | - |
Homo sapiens | - |
| 3.4.24.B12 | chondrocyte | - |
Bos taurus | - |
| 3.4.24.B12 | mesenchymal stem cell | - |
Homo sapiens | - |
| 3.4.24.B12 | synovial fibroblast | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.B12 | aggrecan + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.B12 | aggrecan + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.B12 | aggrecan + H2O | - |
Bos taurus | ? | - |
? | |
| 3.4.24.B12 | additional information | deglycosylated aggrecan is a poor substrate | Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.24.B12 | a disintegrin and metalloproteinase with thrombospondin motifs-5 | - |
Mus musculus |
| 3.4.24.B12 | a disintegrin and metalloproteinase with thrombospondin motifs-5 | - |
Homo sapiens |
| 3.4.24.B12 | a disintegrin and metalloproteinase with thrombospondin motifs-5 | - |
Bos taurus |
| 3.4.24.B12 | ADAMTS-5 | - |
Mus musculus |
| 3.4.24.B12 | ADAMTS-5 | - |
Homo sapiens |
| 3.4.24.B12 | ADAMTS-5 | - |
Bos taurus |
| 3.4.24.B12 | aggrecanase-2 | - |
Mus musculus |
| 3.4.24.B12 | aggrecanase-2 | - |
Homo sapiens |
| 3.4.24.B12 | aggrecanase-2 | - |
Bos taurus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
