BRENDA - Enzyme Database

Lipin1 regulation by estrogen in uterus and liver: implications for diabetes and fertility

Gowri, P.M.; Sengupta, S.; Bertera, S.; Katzenellenbogen, B.S.; Endocrinology 148, 3685-3693 (2007)

Data extracted from this reference:

Engineering
EC Number
Amino acid exchange
Commentary
Organism
3.1.3.4
additional information
lipin1-deficient mice show reduce fertility, phenotype, overview
Mus musculus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.3.4
cytosol
-
Mus musculus
5829
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.3.4
additional information
Mus musculus
the enzyme is regulated by estrogens in the liver and the uterus, E2 downregulates the enzyme in the uterus via the estrogen receptor in a primary response, overview
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.3.4
Mus musculus
-
nondiabetic C57BL6 and CD-1 mice, and diabetic NOD mice and Pd-NOD mice, gene lipin1
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.3.4
liver
-
Mus musculus
-
3.1.3.4
uterus
predominantly in the glandular and luminal epithelium, apical region, overview
Mus musculus
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
3.1.3.4
additional information
-
expression levels in uteri and livers of nondiabetic C57BL6 and CD-1 mice, and diabetic NOD mice and Pd-NOD mice, overview
Mus musculus
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.3.4
additional information
the enzyme is regulated by estrogens in the liver and the uterus, E2 downregulates the enzyme in the uterus via the estrogen receptor in a primary response, overview
679521
Mus musculus
?
-
-
-
-
3.1.3.4
phosphatidic acid + H2O
-
679521
Mus musculus
?
-
-
-
?
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
3.1.3.4
additional information
lipin1-deficient mice show reduce fertility, phenotype, overview
Mus musculus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.3.4
cytosol
-
Mus musculus
5829
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.3.4
additional information
Mus musculus
the enzyme is regulated by estrogens in the liver and the uterus, E2 downregulates the enzyme in the uterus via the estrogen receptor in a primary response, overview
?
-
-
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.3.4
liver
-
Mus musculus
-
3.1.3.4
uterus
predominantly in the glandular and luminal epithelium, apical region, overview
Mus musculus
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
3.1.3.4
additional information
-
expression levels in uteri and livers of nondiabetic C57BL6 and CD-1 mice, and diabetic NOD mice and Pd-NOD mice, overview
Mus musculus
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.3.4
additional information
the enzyme is regulated by estrogens in the liver and the uterus, E2 downregulates the enzyme in the uterus via the estrogen receptor in a primary response, overview
679521
Mus musculus
?
-
-
-
-
3.1.3.4
phosphatidic acid + H2O
-
679521
Mus musculus
?
-
-
-
?