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Literature summary extracted from

  • Bhutani, N.; Venkatraman, P.; Goldberg, A.L.
    Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation (2007), EMBO J., 26, 1385-1396.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.14 bestatin 0.1 mM Homo sapiens
3.4.11.14 puromycin 0.1 mM Homo sapiens
3.4.14.10 butabindide specific TPPII inhibitor Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.11.4 cytosol
-
Oryctolagus cuniculus 5829
-
3.4.11.14 cytosol
-
Homo sapiens 5829
-
3.4.14.10 cytosol
-
Homo sapiens 5829
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.4 Oryctolagus cuniculus
-
-
-
3.4.11.14 Homo sapiens
-
-
-
3.4.14.10 Homo sapiens P29144
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.11.4 DE-52 column chromatography and Resource Q column chromatography Oryctolagus cuniculus
3.4.14.10 DEAE column chromatography and Resource RPC hydrophobic column chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.4 muscle
-
Oryctolagus cuniculus
-
3.4.11.14 HeLa cell
-
Homo sapiens
-
3.4.14.10 HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.4 (Gln)17-Arg-Arg-Gly-Arg-Arg + H2O little activity Oryctolagus cuniculus (Gln)14-Arg-Arg-Gly-Arg-Arg + Gln-Gln-Gln
-
?
3.4.11.4 (Gln)20-Arg-Arg-Gly-Arg-Arg + H2O little activity Oryctolagus cuniculus (Gln)17-Arg-Arg-Gly-Arg-Arg + Gln-Gln-Gln
-
?
3.4.11.4 additional information no digestion is observed against Lys-Lys-(Gln)30-Lys-Lys Oryctolagus cuniculus ?
-
?
3.4.11.14 CKKQ20KK + H2O
-
Homo sapiens ?
-
?
3.4.11.14 KKE-(5-[(2-aminoethyl) amino]-naphthalene-1-sulfonic acid)-Q9K-((4'-dimethylaminoazobenzene-4'-sulfonyl))-K + H2O
-
Homo sapiens ?
-
?
3.4.11.14 KKQ30KK + H2O
-
Homo sapiens ?
-
?
3.4.11.14 poly-Glu peptide + H2O capable of rapidly digesting poly-Q sequences Homo sapiens ?
-
?
3.4.14.10 Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O
-
Homo sapiens Ala-Ala-Phe + 7-amino-4-methylcoumarin
-
?
3.4.14.10 Gln-7-amido-4-methylcoumarin + H2O
-
Homo sapiens Gln + 7-amino-4-methylcoumarin
-
?
3.4.14.10 KKE-5-[(2-aminoethyl) amino]-naphthalene-1-sulfonic acid-Q9K-4'-dimethylaminoazobenzene-4'-sulfonyl + H2O
-
Homo sapiens ?
-
?
3.4.14.10 additional information no activity against Q20RRGRR and KKQ30KK Homo sapiens ?
-
?
3.4.14.10 Q20RRGRR + H2O little activity Homo sapiens Q17RRGRR + Q14RRGRR + QQQ
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.4 TPPII
-
Oryctolagus cuniculus
3.4.11.4 tripeptidyl peptidase II
-
Oryctolagus cuniculus
3.4.11.14 PSA
-
Homo sapiens
3.4.11.14 puromycin-sensitive aminopeptidase
-
Homo sapiens
3.4.14.10 TPII
-
Homo sapiens
3.4.14.10 tripeptidyl peptidase
-
Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.14.10 7
-
-
Homo sapiens