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Literature summary extracted from

  • St-Laurent, J.F.; Gagnon, S.N.; Dequen, F.; Hardy, I.; Desnoyers, S.
    Altered DNA damage response in Caenorhabditis elegans with impaired poly(ADP-ribose) glycohydrolases genes expression (2007), DNA Repair, 6, 329-343.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.2.1.143 expression in Escherichia coli as His-tagged protein Caenorhabditis elegans

Protein Variants

EC Number Protein Variants Comment Organism
3.2.1.143 D253N decrease in catalytic activity Caenorhabditis elegans
3.2.1.143 D536N loss of catalytic activity Caenorhabditis elegans
3.2.1.143 E271N complete loss of catalytic activity Caenorhabditis elegans
3.2.1.143 E272N complete loss of catalytic activity Caenorhabditis elegans
3.2.1.143 E554N decrease in catalytic activity Caenorhabditis elegans
3.2.1.143 E555N loss of catalytic activity Caenorhabditis elegans
3.2.1.143 additional information enzyme knock-down by RNAi results in increased radiation sensitivity of worms Caenorhabditis elegans
3.2.1.143 Y311A almost complete loss of catalytic activity Caenorhabditis elegans
3.2.1.143 Y594A decrease in catalytic activity Caenorhabditis elegans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.143 cytoplasm
-
 Caenorhabditis elegans 5737
-
3.2.1.143 nucleus
-
 Caenorhabditis elegans 5634
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.2.1.143 55000
-
 x * 55000, SDS-PAGE of His-tagged protein Caenorhabditis elegans
3.2.1.143 91256
-
 x * 91256, calculated for His-tagged protein, x * 138000, SDS-PAGE of His-tagged protein, enzyme behaves abnormally in SDS-PAGE Caenorhabditis elegans
3.2.1.143 138000
-
 x * 91256, calculated for His-tagged protein, x * 138000, SDS-PAGE of His-tagged protein, enzyme behaves abnormally in SDS-PAGE Caenorhabditis elegans

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.143 Caenorhabditis elegans Q867X0 isoforms PME-3, expression throughout the life cycle
-
3.2.1.143 Caenorhabditis elegans Q9N5L4 isoforms PME-4, expression throughout the life cycle
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.143 head predominant expression in nerve cells of head and tail Caenorhabditis elegans
-
3.2.1.143 nerve predominant expression in nerve cells of head and tail Caenorhabditis elegans
-
3.2.1.143 tail predominant expression in nerve cells of head and tail Caenorhabditis elegans
-

Subunits

EC Number Subunits Comment Organism
3.2.1.143 ? x * 55000, SDS-PAGE of His-tagged protein Caenorhabditis elegans
3.2.1.143 ? x * 91256, calculated for His-tagged protein, x * 138000, SDS-PAGE of His-tagged protein, enzyme behaves abnormally in SDS-PAGE Caenorhabditis elegans