Literature summary extracted from

Bembenek, J.N.; Richie, C.T.; Squirrell, J.M.; Campbell, J.M.; Eliceiri, K.W.; Poteryaev, D.; Spang, A.; Golden, A.; White, J.G.
Cortical granule exocytosis in C. elegans is regulated by cell cycle components including separase (2007), Development, 134, 3837-3848.

Application

EC Number	Application	Comment	Organism
3.4.22.49	molecular biology	separase is identified as a key cell cycle component that is required for degranulation	Caenorhabditis elegans

Protein Variants

EC Number	Protein Variants	Comment	Organism
3.4.22.49	additional information	RNAi of sep-1 inhibits degranulation in addition to causing extensive chromosomal segregation failures. Temperature-sensitive sep-1(e2406) allele exhibits similar inhibition of degranulation, but has minimal effects on chromosome segregation	Caenorhabditis elegans

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.4.22.49	additional information	separase localizes to cortically located filamentous structures in prometaphase I upon oocyte maturation. After fertilization, separase disappears from these structures and appears on cortical granules by anaphase I	Caenorhabditis elegans	-	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.22.49	Caenorhabditis elegans	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.22.49	granule cell	-	Caenorhabditis elegans	-

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.22.49	sep-1	-	Caenorhabditis elegans
3.4.22.49	separase	-	Caenorhabditis elegans

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Release 2023.1 (January 2023)