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Literature summary extracted from

  • Zelck, U.E.; Gege, B.E.; Schmid, S.
    Specific inhibitors of mitogen-activated protein kinase and PI3-K pathways impair immune responses by hemocytes of trematode intermediate host snails (2007), Dev. Comp. Immunol., 31, 321-331.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.11.24 additional information MAPK signal transduction pathway plays a pivotal role in the immune responses of snail hemocytes. ERK appears to strongly regulate cell motility. ERK, JNK and p38 contribute to phagocytosis-mediated signal transduction. ERK also plays a major role in oxidative burst activation and the encapsulation of trematode larvae by snail hemocytes Lymnaea stagnalis
2.7.11.24 additional information MAPK signal transduction pathway plays a pivotal role in the immune responses of snail hemocytes. ERK appears to strongly regulate cell motility. ERK, JNK and p38 contribute to phagocytosis-mediated signal transduction. ERK also plays a major role in oxidative burst activation and the encapsulation of trematode larvae by snail hemocytes Biomphalaria glabrata

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.24 PD098059 ERK inhibitor, significantly reduces hemocyte spreading in a dose-dependent manner, impairs sheep red blood cell phagocytosis, severely inhibits H2O2 production during phagocytosis, significantly impairs the cellular encapsulation of trematode larvae and H2O2 production during encapsulation Biomphalaria glabrata
2.7.11.24 PD098059 ERK inhibitor, significantly reduces hemocyte spreading in a dose-dependent manner, impairs sheep red blood cell phagocytosis, severely inhibits H2O2 production during phagocytosis, significantly impairs the cellular encapsulation of trematode larvae and H2O2 production during encapsulation Lymnaea stagnalis
2.7.11.24 SB203580 p38 kinase inhibitor,has no effect on hemocyte spreading, impairs sheep red blood cell phagocytosis Biomphalaria glabrata
2.7.11.24 SB203580 p38 kinase inhibitor,has no effect on hemocyte spreading, impairs sheep red blood cell phagocytosis Lymnaea stagnalis
2.7.11.24 SP600125 JNK inhibitor has no effect on hemocyte spreading, impairs sheep red blood cell phagocytosis Biomphalaria glabrata
2.7.11.24 SP600125 JNK inhibitor has no effect on hemocyte spreading, impairs sheep red blood cell phagocytosis Lymnaea stagnalis

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.24 Biomphalaria glabrata
-
 strains 13-16-R1 and M-line
-
2.7.11.24 Lymnaea stagnalis
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.24 hemocyte
-
 Lymnaea stagnalis
-
2.7.11.24 hemocyte
-
 Biomphalaria glabrata
-

Synonyms

EC Number Synonyms Comment Organism
2.7.11.24 ERK1
-
 Lymnaea stagnalis
2.7.11.24 ERK1
-
 Biomphalaria glabrata
2.7.11.24 ERK2
-
 Lymnaea stagnalis
2.7.11.24 ERK2
-
 Biomphalaria glabrata
2.7.11.24 extracellular-signal regulated kinase 1
-
 Lymnaea stagnalis
2.7.11.24 extracellular-signal regulated kinase 1
-
 Biomphalaria glabrata
2.7.11.24 extracellular-signal regulated kinase 2
-
 Lymnaea stagnalis
2.7.11.24 extracellular-signal regulated kinase 2
-
 Biomphalaria glabrata
2.7.11.24 JNK
-
 Lymnaea stagnalis
2.7.11.24 JNK
-
 Biomphalaria glabrata
2.7.11.24 MAPK
-
 Lymnaea stagnalis
2.7.11.24 MAPK
-
 Biomphalaria glabrata
2.7.11.24 mitogen-activated protein kinase
-
 Lymnaea stagnalis
2.7.11.24 mitogen-activated protein kinase
-
 Biomphalaria glabrata
2.7.11.24 p38
-
 Lymnaea stagnalis
2.7.11.24 p38
-
 Biomphalaria glabrata