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Literature summary extracted from

  • Walker, M.B.; Miller, C.T.; Coffin Talbot, J.; Stock, D.W.; Kimmel, C.B.
    Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning (2006), Dev. Biol., 295, 194-205.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.21.75 additional information furin A activates endothelin 1 signaling Danio rerio
3.4.21.75 additional information furin B activates endothelin 1 signaling Danio rerio

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.75 additional information loss of furin A function causes only a partial loss of endothelin 1 function. Furin A mutants typically have wild-type looking anterior arch ventral cartilages that are abnormally fused to dorsal cartilages. Cartilages of the posterior arches are also typically wild type, with a low penetrance of cartilage reduction observed in the third and fourth arches. Shape changes and bony fusions between the opercle and posterior branchiostegal ray, and altered muscle insertion points near joint domains. Arches fail to correctly undergo ventral elongation before skeletogenesis begins. Furin A mutants have defects in intermediate domain elements of the pharyngeal skeleton and mildly ruffled fins. Expression of endothelin 1-dependent genes is downregulated. Later in development, expression of most of these genes recovers to near wild-type levels Danio rerio

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.75 Danio rerio Q1KHF8
-
-
3.4.21.75 Danio rerio Q1KHF9
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.75 embryo
-
 Danio rerio
-

Synonyms

EC Number Synonyms Comment Organism
3.4.21.75 furin A
-
 Danio rerio
3.4.21.75 furin B
-
 Danio rerio