EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.22.69 | (S)-2-((2S,3R)-2-((S)-2-acetamido-3-methylbutanamido)-3-(benzyloxy)butanamido)-4-methyl-N-((S)-4-(5-nitro-1,4-dioxo-3,4-dihydrophthalazin-2(1H)-yl)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)pentanamide | - |
Severe acute respiratory syndrome-related coronavirus | |
3.4.22.69 | 1-(1-benzothiophen-2-ylmethyl)-5-iodo-1H-indole-2,3-dione | - |
Severe acute respiratory syndrome-related coronavirus | |
3.4.22.69 | 1-(2-naphthylmethyl)-2,3-dioxoindoline-5-carboxamide | - |
Severe acute respiratory syndrome-related coronavirus | |
3.4.22.69 | 1-[bis(4-chlorophenyl)methyl]-3-[2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazol-3-ium | - |
Severe acute respiratory syndrome-related coronavirus | |
3.4.22.69 | 2-(4-aminophenyl)-6-methyl-1H-benzimidazole-7-sulfonic acid | - |
Severe acute respiratory syndrome-related coronavirus | |
3.4.22.69 | 2-([N-[(benzyloxy)carbonyl]-L-alanyl-L-valyl]amino)-5-[[(2S,5S)-5-[[(benzyloxy)carbonyl]amino]-2-(1-methylethyl)-4-oxohexanoyl]amino]-1,2,5,6-tetradeoxy-1,6-diphenyl-L-iditol | - |
Severe acute respiratory syndrome-related coronavirus | |
3.4.22.69 | 2-phenylethyl 2-methyl-4-(2-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate | - |
Severe acute respiratory syndrome-related coronavirus | |
3.4.22.69 | 3,4-dichloro-5-[2-(5-chloro-3-methyl-1-benzothien-2-yl)-2-oxoethyl]furan-2(5H)-one | - |
Severe acute respiratory syndrome-related coronavirus | |
3.4.22.69 | 5-chloropyridin-3-yl thiophene-2-carboxylate | - |
Severe acute respiratory syndrome-related coronavirus | |
3.4.22.69 | bis[1,3]thiazolo[4,5-b:5',4'-e]pyridine-2,6-diamine | - |
Severe acute respiratory syndrome-related coronavirus | |
3.4.22.69 | cinanserin | - |
Severe acute respiratory syndrome-related coronavirus | |
3.4.22.69 | Hexachlorophene | - |
Severe acute respiratory syndrome-related coronavirus | |
3.4.22.69 | methyl 4-hydroxy-6-(trifluoromethyl)furo[2,3-b]pyridine-2-carboxylate | - |
Severe acute respiratory syndrome-related coronavirus | |
3.4.22.69 | N-(2-chloro-4-nitrophenyl)-Nalpha-[[4-(dimethylamino)phenyl]carbonyl]phenylalaninamide | - |
Severe acute respiratory syndrome-related coronavirus | |
3.4.22.69 | [benzene-1,4-diylbis[carbamoyl(5-nitrobenzene-3,1-diyl)]]diboronic acid | - |
Severe acute respiratory syndrome-related coronavirus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.22.69 | Severe acute respiratory syndrome-related coronavirus | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.22.69 | AAVLQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | AAVLQ + SGF-NH2 | - |
? | |
3.4.22.69 | ATVRLQAGNAT + H2O | - |
Severe acute respiratory syndrome-related coronavirus | ATVRLQ + AGNAT | - |
? | |
3.4.22.69 | AVLQS-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | AVLQ + L-serinamide | - |
? | |
3.4.22.69 | AVLQSE-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | AVLQ + Ser-Glu-NH2 | - |
? | |
3.4.22.69 | AVLQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | AVLQ + SGF-NH2 | - |
? | |
3.4.22.69 | FYPKLQASQAW + H2O | - |
Severe acute respiratory syndrome-related coronavirus | FYPKLQ + ASQAW | - |
? | |
3.4.22.69 | KVATVQSKMSD + H2O | - |
Severe acute respiratory syndrome-related coronavirus | KVATVQ + SKMSD | - |
? | |
3.4.22.69 | LAVLQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | LAVLQ + SGF-NH2 | - |
? | |
3.4.22.69 | LQSG-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | Leu-Gln + Ser-Gly-NH2 | - |
? | |
3.4.22.69 | NRATLQAIASE + H2O | - |
Severe acute respiratory syndrome-related coronavirus | NRATLQ + AIASE | - |
? | |
3.4.22.69 | NVATLQAENVT + H2O | - |
Severe acute respiratory syndrome-related coronavirus | NVATLQ + AENVT | - |
? | |
3.4.22.69 | PATVLQAVGAC + H2O | - |
Severe acute respiratory syndrome-related coronavirus | PATVLQ + AVGAC | - |
? | |
3.4.22.69 | REPLMQSADAS + H2O | - |
Severe acute respiratory syndrome-related coronavirus | REPLMQ + SADAS | - |
? | |
3.4.22.69 | SAALQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAALQ + SGF-NH2 | - |
? | |
3.4.22.69 | SAKLQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAKLQ + SGF-NH2 | - |
? | |
3.4.22.69 | SALLQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SALLQ + SGF-NH2 | - |
? | |
3.4.22.69 | SATLQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SATLQ + SGF-NH2 | - |
? | |
3.4.22.69 | SAVAQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAVAQ + SGF-NH2 | - |
? | |
3.4.22.69 | SAVFQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAVMQ + SGF-NH2 | - |
? | |
3.4.22.69 | SAVIQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAVIQ + SGF-NH2 | - |
? | |
3.4.22.69 | SAVKLQNNELS + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAVKLQ + NNELS | - |
? | |
3.4.22.69 | SAVLESGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAVLE + SGF-NH2 | - |
? | |
3.4.22.69 | SAVLKSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAVLK + SGF-NH2 | - |
? | |
3.4.22.69 | SAVLNSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAVLN + SGF-NH | - |
? | |
3.4.22.69 | SAVLQAGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAVLQ + AGF-NH2 | - |
? | |
3.4.22.69 | SAVLQGGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAVLQ + GGF-NH2 | - |
? | |
3.4.22.69 | SAVLQLGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAVLQ + LGF-NH2 | - |
? | |
3.4.22.69 | SAVLQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAVLQ + SGF-NH2 | - |
? | |
3.4.22.69 | SAVMQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAVMQ + SGF-NH2 | - |
? | |
3.4.22.69 | SAVRQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAVRQ + SGF-NH2 | - |
? | |
3.4.22.69 | SAVVQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAVVQ + SGF-NH2 | - |
? | |
3.4.22.69 | SGVTFQGKFKK + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SGVTFQ + GKFKK | - |
? | |
3.4.22.69 | SLVLQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SLVLQ + SGF-NH2 | - |
? | |
3.4.22.69 | STVLQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | STVLQ + SGF-NH2 | - |
? | |
3.4.22.69 | SVVLQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SVVLQ + SGF-NH2 | - |
? | |
3.4.22.69 | TAVLQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | TAVLQ + SGF-NH2 | - |
? | |
3.4.22.69 | TFTRLQSLENV + H2O | - |
Severe acute respiratory syndrome-related coronavirus | TFTRLQ + SLENV | - |
? | |
3.4.22.69 | TSAVLQSGFRK-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | TSAVLQ + SGFRK-NH2 | - |
? | |
3.4.22.69 | TVKLQAGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | TVKLQ + AGF-NH2 | - |
? | |
3.4.22.69 | TVTLQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | TVTLQ + SGF-NH2 | - |
? | |
3.4.22.69 | TVVLQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | TVVLQ + SGF-NH2 | - |
? | |
3.4.22.69 | VLQS-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | VLQ + L-serinamide | - |
? | |
3.4.22.69 | VLQSG-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | VLQ + Ser-Gly-NH2 | - |
? | |
3.4.22.69 | VVTLQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | VVTLQ + SGF-NH2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.22.69 | SARS 3C-like proteinase | - |
Severe acute respiratory syndrome-related coronavirus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.22.69 | 7.4 | - |
wild-type enzyme | Severe acute respiratory syndrome-related coronavirus |
3.4.22.69 | 7.6 | - |
mutant enzyme C145S | Severe acute respiratory syndrome-related coronavirus |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
3.4.22.69 | 6.3 | 9.3 | pH 6.3: about 55% of maximal activity, pH 9.3: about 45% of maximal activity, mutant enzyme C145S | Severe acute respiratory syndrome-related coronavirus |
3.4.22.69 | 6.3 | 8.7 | pH 6.3: about 55% of maximal activity, pH 8.7: about 45% of maximal activity, wild-type enzyme | Severe acute respiratory syndrome-related coronavirus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.22.69 | 0.00003 | - |
N-(2-chloro-4-nitrophenyl)-Nalpha-[[4-(dimethylamino)phenyl]carbonyl]phenylalaninamide | - |
Severe acute respiratory syndrome-related coronavirus | |
3.4.22.69 | 0.00004 | - |
[benzene-1,4-diylbis[carbamoyl(5-nitrobenzene-3,1-diyl)]]diboronic acid | - |
Severe acute respiratory syndrome-related coronavirus | |
3.4.22.69 | 0.0006 | - |
2-([N-[(benzyloxy)carbonyl]-L-alanyl-L-valyl]amino)-5-[[(2S,5S)-5-[[(benzyloxy)carbonyl]amino]-2-(1-methylethyl)-4-oxohexanoyl]amino]-1,2,5,6-tetradeoxy-1,6-diphenyl-L-iditol | - |
Severe acute respiratory syndrome-related coronavirus | |
3.4.22.69 | 0.0137 | - |
Hexachlorophene | - |
Severe acute respiratory syndrome-related coronavirus | |
3.4.22.69 | 0.061 | - |
1-[bis(4-chlorophenyl)methyl]-3-[2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazol-3-ium | - |
Severe acute respiratory syndrome-related coronavirus |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
3.4.22.69 | 0.00006 | - |
- |
Severe acute respiratory syndrome-related coronavirus | N-(2-chloro-4-nitrophenyl)-Nalpha-[[4-(dimethylamino)phenyl]carbonyl]phenylalaninamide | |
3.4.22.69 | 0.00037 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 1-(2-naphthylmethyl)-2,3-dioxoindoline-5-carboxamide | |
3.4.22.69 | 0.0005 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 5-chloropyridin-3-yl thiophene-2-carboxylate | |
3.4.22.69 | 0.0006 | - |
- |
Severe acute respiratory syndrome-related coronavirus | (S)-2-((2S,3R)-2-((S)-2-acetamido-3-methylbutanamido)-3-(benzyloxy)butanamido)-4-methyl-N-((S)-4-(5-nitro-1,4-dioxo-3,4-dihydrophthalazin-2(1H)-yl)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)pentanamide | |
3.4.22.69 | 0.00095 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 1-(1-benzothiophen-2-ylmethyl)-5-iodo-1H-indole-2,3-dione | |
3.4.22.69 | 0.0025 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 2-phenylethyl 2-methyl-4-(2-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate | |
3.4.22.69 | 0.0026 | - |
- |
Severe acute respiratory syndrome-related coronavirus | bis[1,3]thiazolo[4,5-b:5',4'-e]pyridine-2,6-diamine | |
3.4.22.69 | 0.0043 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 2-(4-aminophenyl)-6-methyl-1H-benzimidazole-7-sulfonic acid | |
3.4.22.69 | 0.007 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 3,4-dichloro-5-[2-(5-chloro-3-methyl-1-benzothien-2-yl)-2-oxoethyl]furan-2(5H)-one | |
3.4.22.69 | 0.007 | - |
- |
Severe acute respiratory syndrome-related coronavirus | methyl 4-hydroxy-6-(trifluoromethyl)furo[2,3-b]pyridine-2-carboxylate |