BRENDA - Enzyme Database show

Diphenyl diselenide [(PhSe)(2)] inhibits Drosophila melanogaster delta-aminolevulinate dehydratase (delta-ALA-D) gene transcription and enzyme activity

Golombieski, R.M.; Graichen, D.A.; Pivetta, L.A.; Nogueira, C.W.; Loreto, E.L.; Rocha, J.B.; Comp. Biochem. Physiol. C Toxicol. Pharmacol. 147, 198-204 (2008)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
4.2.1.24
diphenyl diselenide
-
Mus musculus
4.2.1.24
Pb2+
-
Mus musculus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.2.1.24
Mus musculus
-
swiss mice
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.24
5-aminolevulinate + 5-aminolevulinate
-
679350
Mus musculus
porphobilinogen + 2 H2O
-
-
-
?
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
4.2.1.24
6.5
-
-
Mus musculus
IC50 Value
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
4.2.1.24
0.00195
-
37°C, pH 6.5
Mus musculus
diphenyl diselenide
4.2.1.24
0.0056
-
37°C, pH 8.5
Mus musculus
Pb2+
4.2.1.24
0.0062
-
37°C, pH 6.5
Mus musculus
Pb2+
IC50 Value (protein specific)
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
4.2.1.24
0.00195
-
37°C, pH 6.5
Mus musculus
diphenyl diselenide
4.2.1.24
0.0056
-
37°C, pH 8.5
Mus musculus
Pb2+
4.2.1.24
0.0062
-
37°C, pH 6.5
Mus musculus
Pb2+
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
4.2.1.24
diphenyl diselenide
-
Mus musculus
4.2.1.24
Pb2+
-
Mus musculus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.24
5-aminolevulinate + 5-aminolevulinate
-
679350
Mus musculus
porphobilinogen + 2 H2O
-
-
-
?
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
4.2.1.24
6.5
-
-
Mus musculus