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Literature summary extracted from

  • Caselli, F.; Gastaldi, L.; Gambi, N.; Fabbri, E.
    In vitro characterization of cholinesterases in the earthworm Eisenia andrei (2006), Comp. Biochem. Physiol. C, 143C, 416-421.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 BW284c51 specific inhibition of acetylthiocholinesterase activity Eisenia andrei
3.1.1.7 Carbaryl
-
 Eisenia andrei
3.1.1.7 eserine
-
 Eisenia andrei
3.1.1.7 additional information no inhibition by iso-OMPA Eisenia andrei
3.1.1.8 BW284c51 specific inhibition of acetylthiocholinesterase activity Eisenia andrei
3.1.1.8 Carbaryl
-
 Eisenia andrei
3.1.1.8 eserine
-
 Eisenia andrei
3.1.1.8 additional information no inhibition by iso-OMPA Eisenia andrei

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.7 0.142
-
 acetylthiocholine iodide pH 7.4, 25°C Eisenia andrei
3.1.1.7 0.183
-
 propionylthiocholine iodide pH 7.4, 25°C Eisenia andrei
3.1.1.8 0.142
-
 acetylthiocholine iodide pH 7.4, 25°C Eisenia andrei
3.1.1.8 0.183
-
 propionylthiocholine iodide pH 7.4, 25°C Eisenia andrei

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Eisenia andrei
-
-
-
3.1.1.8 Eisenia andrei
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.7 0.004
-
 substrate butyrylthiocholine iodide Eisenia andrei
3.1.1.7 0.0425
-
 substrate acetylthiocholine iodide Eisenia andrei
3.1.1.7 0.0498
-
 substrate propionylthiocholine iodide Eisenia andrei
3.1.1.8 0.004
-
 substrate butyrylthiocholine iodide Eisenia andrei
3.1.1.8 0.0425
-
 substrate acetylthiocholine iodide Eisenia andrei
3.1.1.8 0.0498
-
 substrate propionylthiocholine iodide Eisenia andrei

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.7 acetylthiocholine iodide + H2O
-
 Eisenia andrei thiocholine iodide + acetate
-
 ?
3.1.1.7 butyrylthiocholine iodide + H2O
-
 Eisenia andrei thiocholine iodide + butyrate
-
 ?
3.1.1.7 propionylthiocholine iodide + H2O preferred substrate Eisenia andrei thiocholine iodide + propionate
-
 ?
3.1.1.8 acetylthiocholine iodide + H2O
-
 Eisenia andrei thiocholine + acetate
-
 ?
3.1.1.8 butyrylthiocholine iodide + H2O
-
 Eisenia andrei thiocholine + butyrate
-
 ?
3.1.1.8 propionylthiocholine iodide + H2O preferred substrate Eisenia andrei thiocholine + propionate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.7 ChE
-
 Eisenia andrei
3.1.1.7 cholinesterase
-
 Eisenia andrei
3.1.1.7 More cf. EC 3.1.1.8 Eisenia andrei
3.1.1.8 ChE
-
 Eisenia andrei
3.1.1.8 cholinesterase
-
 Eisenia andrei
3.1.1.8 More cf. EC 3.1.1.7 Eisenia andrei

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.7 25
-
 assay at Eisenia andrei
3.1.1.8 25
-
 assay at Eisenia andrei

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.7 7.4
-
 assay at Eisenia andrei
3.1.1.8 7.4
-
 assay at Eisenia andrei

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.1.7 0.00000479
-
 pH 7.4, 25°C, versus propionylthiocholine Eisenia andrei Carbaryl
3.1.1.7 0.00000575
-
 pH 7.4, 25°C, versus acetylthiocholine Eisenia andrei Carbaryl
3.1.1.7 0.000012
-
 pH 7.4, 25°C, versus propionylthiocholine Eisenia andrei eserine
3.1.1.7 0.0000144
-
 pH 7.4, 25°C, versus acetylthiocholine Eisenia andrei eserine
3.1.1.8 0.00000479
-
 pH 7.4, 25°C, versus propionylthiocholine Eisenia andrei Carbaryl
3.1.1.8 0.00000575
-
 pH 7.4, 25°C, versus acetylthiocholine Eisenia andrei Carbaryl
3.1.1.8 0.000012
-
 pH 7.4, 25°C, versus propionylthiocholine Eisenia andrei eserine
3.1.1.8 0.0000144
-
 pH 7.4, 25°C, versus acetylthiocholine Eisenia andrei eserine