EC Number | Application | Comment | Organism |
---|---|---|---|
4.4.1.20 | medicine | damaged or inflamed bronchial epithelium may synthesize leukotrienes that contribute directly to bronchoconstriction and leucocytosis in airway inflammation, LTC4 synthase is constitutively expressed in primary bronchial epithelial cells and in the 16-HBE 14o-cell line | Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.3.2.6 | 68000 | - |
determinend by SDS-PAGE and Western Blot analysis | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.3.2.6 | (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O | Homo sapiens | - |
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.3.2.6 | Homo sapiens | - |
- |
- |
4.4.1.20 | Homo sapiens | Q16873 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.3.2.6 | 16HBE14o cell | - |
Homo sapiens | - |
3.3.2.6 | bronchial epithelial cell | HBEC | Homo sapiens | - |
3.3.2.6 | eosinophil | used as control for the expression of 5-LO pathway enzymes | Homo sapiens | - |
3.3.2.6 | HeLa cell | used as control for the expression of 5-LO pathway enzymes | Homo sapiens | - |
3.3.2.6 | KU-812F cell | used as control for the expression of 5-LO pathway enzymes | Homo sapiens | - |
3.3.2.6 | leukocyte | used as control for the expression of 5-LO pathway enzymes | Homo sapiens | - |
4.4.1.20 | bronchial epithelial cell | - |
Homo sapiens | - |
4.4.1.20 | bronchial epithelial cell line | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.3.2.6 | (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O | - |
Homo sapiens | (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate | - |
? | |
4.4.1.20 | leukotriene A4 + glutathione | - |
Homo sapiens | leukotriene C4 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.3.2.6 | leukotriene-A4 hydrolase | - |
Homo sapiens |
4.4.1.20 | leukotriene C4 synthetase | - |
Homo sapiens |
4.4.1.20 | LTC4 synthase | - |
Homo sapiens |
4.4.1.20 | LTC4S | - |
Homo sapiens |