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Literature summary extracted from

  • Jame, A.J.; Lackie, P.M.; Cazaly, A.M.; Sayers, I.; Penrose, J.F.; Holgate, S.T.; Sampson, A.P.
    Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4 (2007), Clin. Exp. Allergy, 37, 880-892.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.4.1.20 medicine damaged or inflamed bronchial epithelium may synthesize leukotrienes that contribute directly to bronchoconstriction and leucocytosis in airway inflammation, LTC4 synthase is constitutively expressed in primary bronchial epithelial cells and in the 16-HBE 14o-cell line Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.3.2.6 68000
-
determinend by SDS-PAGE and Western Blot analysis Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.3.2.6 (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O Homo sapiens
-
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.6 Homo sapiens
-
-
-
4.4.1.20 Homo sapiens Q16873
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.6 16HBE14o cell
-
Homo sapiens
-
3.3.2.6 bronchial epithelial cell HBEC Homo sapiens
-
3.3.2.6 eosinophil used as control for the expression of 5-LO pathway enzymes Homo sapiens
-
3.3.2.6 HeLa cell used as control for the expression of 5-LO pathway enzymes Homo sapiens
-
3.3.2.6 KU-812F cell used as control for the expression of 5-LO pathway enzymes Homo sapiens
-
3.3.2.6 leukocyte used as control for the expression of 5-LO pathway enzymes Homo sapiens
-
4.4.1.20 bronchial epithelial cell
-
Homo sapiens
-
4.4.1.20 bronchial epithelial cell line
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.6 (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O
-
Homo sapiens (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
-
?
4.4.1.20 leukotriene A4 + glutathione
-
Homo sapiens leukotriene C4
-
?

Synonyms

EC Number Synonyms Comment Organism
3.3.2.6 leukotriene-A4 hydrolase
-
Homo sapiens
4.4.1.20 leukotriene C4 synthetase
-
Homo sapiens
4.4.1.20 LTC4 synthase
-
Homo sapiens
4.4.1.20 LTC4S
-
Homo sapiens