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Literature summary extracted from

  • Gros, R.; Ding, Q.; Chorazyczewski, J.; Pickering, J.G.; Limbird, L.E.; Feldman, R.D.
    Adenylyl cyclase isoform-selective regulation of vascular smooth muscle proliferation and cytoskeletal reorganization (2006), Circ. Res., 99, 845-852.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.1 forskolin forskolin-stimulated cAMP production is significantly increased to levels that do not differ between isoforms following the expression of AC1, AC2, AC5, or AC6 Rattus norvegicus
4.6.1.1 isoproterenol stimulates AC6 resulting in a significant increase in the arborization process Rattus norvegicus

Application

EC Number Application Comment Organism
4.6.1.1 additional information isoform-selective signaling complexes likely contribute to various functional consequences of cAMP elevation in vascular smooth muscle cells. AC1 isoform contributes to modulation of extracellular signal-regulated kinase signaling, proliferation, and control of cell division, whereas AC6, at least partly because of uncoupling of cAMP synthesis from cAMP breakdown, results in sustained cAMP accumulation, vasodilator-stimulated phosphoprotein phosphorylation, and control of cytoskeletal rearrangements that contribute to vascular arborization Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.6.1.1 HEK293 cells transiently transfected with pcDNA3 containing either GFP or Flag-tagged AC1, AC2 and AC5 or AC6 cDNA Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.1 siRNA selectively reduces heterologous expression of AC6 without impact on the expression of AC2, reduces forskolin-activated AC6 activity, whereby diminishing forskolin-induced arborization Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.1 Rattus norvegicus
-
 male Wistar rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.1 aortic smooth muscle
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.1 ATP cAMP synthesis by the AC6 isoform is not tightly coupled to cAMP hydrolysis, whereas for the other AC isoforms cAMP synthesis and hydrolysis are much more tightly linked Rattus norvegicus 3',5'-cAMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.1 AC1
-
 Rattus norvegicus
4.6.1.1 AC2
-
 Rattus norvegicus
4.6.1.1 AC5
-
 Rattus norvegicus
4.6.1.1 AC6
-
 Rattus norvegicus