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Literature summary extracted from

  • Payne, R.J.; Peyrot, F.; Kerbarh, O.; Abell, A.D.; Abell, C.
    Rational design, synthesis, and evaluation of nanomolar type II dehydroquinase inhibitors (2007), ChemMedChem, 2, 1015-1029.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.10 additional information the in silico design, synthesis, and biological evaluation of ten potent type II dehydroquinase inhibitors are described. These compounds contain an anhydroquinate core, incorporated as a mimic of the enolate reaction intermediate. This substructure is attached by a variety of linking units to a terminal phenyl group that binds in an adjacent pocket. Inhibitors are synthesised from (-)-quinic acid using palladium-catalysed Stille and carboamidation chemistry. Several inhibitors exhibited nanomolar inhibition constants Mycobacterium tuberculosis
4.2.1.10 additional information the in silico design, synthesis, and biological evaluation of ten potent type II dehydroquinase inhibitors are described. These compounds contain an anhydroquinate core, incorporated as a mimic of the enolate reaction intermediate. This substructure is attached by a variety of linking units to a terminal phenyl group that binds in an adjacent pocket. Inhibitors are synthesised from (-)-quinic acid using palladium-catalysed Stille and carboamidation chemistry. Several inhibitors exhibited nanomolar inhibition constants Streptomyces coelicolor

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.10 Mycobacterium tuberculosis
-
-
-
4.2.1.10 Streptomyces coelicolor
-
-
-

Synonyms

EC Number Synonyms Comment Organism
4.2.1.10 EC 4.2.1.10
-
Mycobacterium tuberculosis
4.2.1.10 EC 4.2.1.10
-
Streptomyces coelicolor