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Literature summary extracted from

  • Toscano, M.D.; Payne, R.J.; Chiba, A.; Kerbarh, O.; Abell, C.
    Nanomolar inhibition of type II dehydroquinase based on the enolate reaction mechanism (2007), ChemMedChem, 2, 101-112.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.10 (1R,4R,5R)-3-(2-carboxy-vinyl)-1,4,5-trihydroxy-cyclohex-2-enecarboxylic acid
-
 Mycobacterium tuberculosis
4.2.1.10 (1R,4R,5R)-3-(2-carboxy-vinyl)-1,4,5-trihydroxy-cyclohex-2-enecarboxylic acid
-
 Streptomyces coelicolor
4.2.1.10 (1R,4R,5R)-3-(tert-butylcarbamoyl)-1,4,5-trihydroxycyclohex-2-enecarboxylic acid
-
 Mycobacterium tuberculosis
4.2.1.10 (1R,4R,5R)-3-(tert-butylcarbamoyl)-1,4,5-trihydroxycyclohex-2-enecarboxylic acid
-
 Streptomyces coelicolor
4.2.1.10 (3R,5R,6R)-3,5,6-trihydroxycyclohex-1-ene-1,3-dicarboxylic acid
-
 Mycobacterium tuberculosis
4.2.1.10 (3R,5R,6R)-3,5,6-trihydroxycyclohex-1-ene-1,3-dicarboxylic acid
-
 Streptomyces coelicolor
4.2.1.10 (3R,5R,6R)-3-carbamoyl-3,5,6-trihydroxycyclohex-1-enecarboxylic acid
-
 Mycobacterium tuberculosis
4.2.1.10 (3R,5R,6R)-3-carbamoyl-3,5,6-trihydroxycyclohex-1-enecarboxylic acid
-
 Streptomyces coelicolor
4.2.1.10 3-hydroxy-cyclohex-1-ene-1,3-dicarboxylic acid
-
 Salmonella enterica subsp. enterica serovar Typhi
4.2.1.10 3-hydroxy-cyclohex-1-ene-1,3-dicarboxylic acid
-
 Streptomyces coelicolor
4.2.1.10 4-hydroxy-2-hydroxymethyl-4-methyl-pent-2-enedioic acid
-
 Salmonella enterica subsp. enterica serovar Typhi
4.2.1.10 4-hydroxy-2-hydroxymethyl-4-methyl-pent-2-enedioic acid
-
 Streptomyces coelicolor
4.2.1.10 4-hydroxy-4-methyl-pent-2-enedioic acid
-
 Salmonella enterica subsp. enterica serovar Typhi
4.2.1.10 4-hydroxy-4-methyl-pent-2-enedioic acid
-
 Streptomyces coelicolor

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.10 Mycobacterium tuberculosis
-
-
-
4.2.1.10 Salmonella enterica subsp. enterica serovar Typhi
-
-
-
4.2.1.10 Streptomyces coelicolor
-
-
-

Synonyms

EC Number Synonyms Comment Organism
4.2.1.10 Type I dehydroquinase
-
 Salmonella enterica subsp. enterica serovar Typhi
4.2.1.10 Type II dehydroquinase
-
 Mycobacterium tuberculosis
4.2.1.10 Type II dehydroquinase
-
 Streptomyces coelicolor

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.2.1.10 0.000032
-
 (3R,5R,6R)-3,5,6-trihydroxycyclohex-1-ene-1,3-dicarboxylic acid pH 7.0 Streptomyces coelicolor
4.2.1.10 0.00024
-
 (3R,5R,6R)-3-carbamoyl-3,5,6-trihydroxycyclohex-1-enecarboxylic acid pH 7.0 Streptomyces coelicolor
4.2.1.10 0.00094
-
 (3R,5R,6R)-3,5,6-trihydroxycyclohex-1-ene-1,3-dicarboxylic acid pH 7.0 Mycobacterium tuberculosis
4.2.1.10 0.016
-
 (3R,5R,6R)-3-carbamoyl-3,5,6-trihydroxycyclohex-1-enecarboxylic acid pH 7.0 Mycobacterium tuberculosis
4.2.1.10 0.025
-
 (1R,4R,5R)-3-(2-carboxy-vinyl)-1,4,5-trihydroxy-cyclohex-2-enecarboxylic acid pH 7.0 Streptomyces coelicolor
4.2.1.10 0.027
-
 (1R,4R,5R)-3-(tert-butylcarbamoyl)-1,4,5-trihydroxycyclohex-2-enecarboxylic acid pH 7.0 Mycobacterium tuberculosis
4.2.1.10 0.029
-
 (1R,4R,5R)-3-(tert-butylcarbamoyl)-1,4,5-trihydroxycyclohex-2-enecarboxylic acid pH 7.0 Streptomyces coelicolor
4.2.1.10 0.105
-
 (1R,4R,5R)-3-(2-carboxy-vinyl)-1,4,5-trihydroxy-cyclohex-2-enecarboxylic acid pH 7.0 Mycobacterium tuberculosis
4.2.1.10 0.47
-
 4-hydroxy-4-methyl-pent-2-enedioic acid pH 7.0 Streptomyces coelicolor
4.2.1.10 0.65
-
 4-hydroxy-2-hydroxymethyl-4-methyl-pent-2-enedioic acid pH 7.0 Salmonella enterica subsp. enterica serovar Typhi
4.2.1.10 0.76
-
 3-hydroxy-cyclohex-1-ene-1,3-dicarboxylic acid pH 7.0 Streptomyces coelicolor
4.2.1.10 0.99
-
 4-hydroxy-4-methyl-pent-2-enedioic acid pH 7.0 Salmonella enterica subsp. enterica serovar Typhi
4.2.1.10 1
-
 4-hydroxy-2-hydroxymethyl-4-methyl-pent-2-enedioic acid pH 7.0 Streptomyces coelicolor
4.2.1.10 1.7
-
 3-hydroxy-cyclohex-1-ene-1,3-dicarboxylic acid pH 7.0 Salmonella enterica subsp. enterica serovar Typhi