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Literature summary extracted from

  • Mills, S.J.; Dozol, H.; Vandeput, F.; Backers, K.; Woodman, T.; Erneux, C.; Spiess, B.; Potter, B.V.
    3-hydroxybenzene 1,2,4-trisphosphate, a novel second messenger mimic and unusual substrate for type-I myo-inositol 1,4,5-trisphosphate 5-phosphatase: Synthesis and physicochemistry (2006), Chembiochem, 7, 1696-1706.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.56 2,3-dihydroxybenzene 1,4-bisphosphate
-
Homo sapiens
3.1.3.56 benzene 1,2,4-trisphosphate
-
Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.56 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.56 brain
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.56 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
-
Homo sapiens 1D-myo-inositol 1,3,4-trisphosphate + phosphate
-
?
3.1.3.56 1D-myo-inositol 1,4,5-trisphosphate + H2O
-
Homo sapiens 1D-myo-inositol 1,4-disphosphate + phosphate
-
?
3.1.3.56 3-hydroxybenzene 1,2,4-trisphosphate + H2O this is the first example of its kind to illustrate that an unnatural aromatic polyphosphorylated molecule can be specifically dephosphorylated by type I Ins(1,4,5)P3 5-phosphatase. No reaction with benzene 1,2,4-trisphosphate Homo sapiens 2,3-dihydroxybenzene 1,4-bisphosphate + phosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.56 InsP3 5-phosphatase
-
Homo sapiens
3.1.3.56 myo-Inositol 1,4,5-trisphosphate 5-phosphatase
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.3.56 37
-
assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.56 7.4
-
assay at Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.3.56 0.014
-
in the presence of 1 mM Ins-(1,4,5)P3 as substrate Homo sapiens benzene 1,2,4-trisphosphate
3.1.3.56 0.021
-
in the presence of 1 mM Ins-(1,4,5)P3 as substrate Homo sapiens 2,3-dihydroxybenzene 1,4-bisphosphate