Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Seiner, D.R.; LaButti, J.N.; Gates, K.S.
    Kinetics and mechanism of protein tyrosine phosphatase 1B inactivation by acrolein (2007), Chem. Res. Toxicol., 20, 1315-1320.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.48 3-methyl-2-butenal 95% remaining activity at 0.5 mM Homo sapiens
3.1.3.48 acetaldehyde more than 95% remaining activity at 0.5 mM Homo sapiens
3.1.3.48 acrolein 4% remaining activity at 0.5 mM, potent irreversible time-dependent inhibitor, addition of 1 mM vanadate slows inactivation of PTP1B by 0.5 mM acrolein Homo sapiens
3.1.3.48 crotonaldehyde 85% remaining activity at 0.5 mM Homo sapiens
3.1.3.48 Glyoxal 93% remaining activity at 0.5 mM Homo sapiens
3.1.3.48 additional information the presence of the superoxide- and hydrogen peroxide-destroying enzymes superoxide dismutase and catalase has no effect on the rate of the inactivation reaction Homo sapiens
3.1.3.48 propanal 93% remaining activity at 0.5 mM Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.48 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.48 p-nitrophenyl phosphate + H2O
-
 Homo sapiens p-nitrophenol + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.48 protein tyrosine phosphatase 1B
-
 Homo sapiens
3.1.3.48 PTP1B
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.3.48 0.00023
-
 acrolein in sodium acetate (100 mM), bis-Tris (50 mM), Tris (50 mM), diethylenetriaminepentaacetic acid (5 mM), and 2,5-dimethylfuran (5% v/v), at pH 7 and 25°C Homo sapiens