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Literature summary extracted from
- Paraoxonase (PON1) polymorphism and activity as the determinants of sensitivity to organophosphates in human subjects (2007), Chem. Biol. Interact., 168, 184-192.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.1.1.2 | gene PON1, genotyping, naturally occuring polymorphisms in the gene coding and the promoter regions affect the activity and the enzyme level | Homo sapiens |
| 3.1.1.2 | genotyping of naturally occuring polymorphisms, allele frequency determination | Homo sapiens |
| 3.1.8.1 | genotyping of naturally occuring polymorphisms, allele frequency determination | Homo sapiens |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.1.1.2 | L55M | naturally occuring polymorphism, allele frequency in relation to exposure of individuals to organophosphates, overview | Homo sapiens |
| 3.1.1.2 | L55M | naturally occuring polymorphism, the paraoxonase activity of the enzyme is altered | Homo sapiens |
| 3.1.1.2 | Q192R | naturally occuring polymorphism, allele frequency in relation to exposure of individuals to organophosphates, overview | Homo sapiens |
| 3.1.1.2 | Q192R | naturally occuring polymorphism, the paraoxonase activity of the enzyme is altered | Homo sapiens |
| 3.1.8.1 | L55M | naturally occuring polymorphism, allele frequency in relation to exposure of individuals to organophosphates, overview | Homo sapiens |
| 3.1.8.1 | Q192R | naturally occuring polymorphism, allele frequency in relation to exposure of individuals to organophosphates, overview | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.2 | organophosphorous compounds | inhibit the enzyme of all genotypes slightly after in vivo exposure | Homo sapiens |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.2 | Ca2+ | required | Homo sapiens |  |
| 3.1.8.1 | Ca2+ | required | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.2 | additional information | Homo sapiens | polymorphisms allele frequency in relation to exposure of individuals to organophosphates, overview | ? | - |
? | |
| 3.1.1.2 | additional information | Homo sapiens | the enzyme is important in the mechanism of organophosphorous toxicity | ? | - |
? | |
| 3.1.1.2 | phenylacetate + H2O | Homo sapiens | - |
phenol + acetate | - |
? | |
| 3.1.8.1 | additional information | Homo sapiens | polymorphisms allele frequency in relation to exposure of individuals to organophosphates, overview | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.2 | Homo sapiens | - |
- |
- |
| 3.1.1.2 | Homo sapiens | P27169 | - |
- |
| 3.1.8.1 | Homo sapiens | P27169 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.1.2 | blood serum | - |
Homo sapiens | - |
| 3.1.1.2 | serum | - |
Homo sapiens | - |
| 3.1.8.1 | blood serum | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.2 | additional information | - |
activity of different genotypes after exposure to high or low organophosphorous compound levels, overview | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.2 | additional information | polymorphisms allele frequency in relation to exposure of individuals to organophosphates, overview | Homo sapiens | ? | - |
? | |
| 3.1.1.2 | additional information | the enzyme is important in the mechanism of organophosphorous toxicity | Homo sapiens | ? | - |
? | |
| 3.1.1.2 | phenylacetate + H2O | - |
Homo sapiens | phenol + acetate | - |
? | |
| 3.1.8.1 | additional information | polymorphisms allele frequency in relation to exposure of individuals to organophosphates, overview | Homo sapiens | ? | - |
? | |
| 3.1.8.1 | paraoxon + H2O | - |
Homo sapiens | diethylphosphate + 4-nitrophenol | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.1.2 | paraoxonase | - |
Homo sapiens |
| 3.1.1.2 | PON1 | - |
Homo sapiens |
| 3.1.8.1 | PON1 | - |
Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.2 | 25 | - |
assay at | Homo sapiens |
| 3.1.8.1 | 25 | - |
assay at | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.2 | 8 | - |
assay at | Homo sapiens |
| 3.1.8.1 | 8 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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