BRENDA - Enzyme Database show

Cadmium inhibits delta-aminolevulinate dehydratase from rat lung in vitro: interaction with chelating and antioxidant agents

Luchese, C.; Zeni, G.; Rocha, J.B.; Nogueira, C.W.; Santos, F.W.; Chem. Biol. Interact. 165, 127-137 (2007)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
4.2.1.24
2,3-dimercaptopropane-1-sulfonic acid
0.1 mM, 20% inhibition, more pronounced inhibition in combination with Cd2+
Rattus norvegicus
4.2.1.24
ascorbic acid
0.4 mM, 23% inhibition
Rattus norvegicus
4.2.1.24
Cd2+
inhibits delta-ALA-D activity. Chelating and antioxidant agents potentiated the inhibition
Rattus norvegicus
4.2.1.24
diphenyl diselenide
0.0005 mM, 17% inhibition
Rattus norvegicus
4.2.1.24
meso-2,3-dimercaptosuccinic acid
0.1 mM, 18% inhibition
Rattus norvegicus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.2.1.24
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
4.2.1.24
lung
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.24
5-aminolevulinate + 5-aminolevulinate
-
679181
Rattus norvegicus
porphobilinogen + 2 H2O
-
-
-
?
IC50 Value
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
4.2.1.24
0.0345
-
pH 6.8, 37°C
Rattus norvegicus
Cd2+
IC50 Value (protein specific)
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
4.2.1.24
0.0345
-
pH 6.8, 37°C
Rattus norvegicus
Cd2+
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
4.2.1.24
2,3-dimercaptopropane-1-sulfonic acid
0.1 mM, 20% inhibition, more pronounced inhibition in combination with Cd2+
Rattus norvegicus
4.2.1.24
ascorbic acid
0.4 mM, 23% inhibition
Rattus norvegicus
4.2.1.24
Cd2+
inhibits delta-ALA-D activity. Chelating and antioxidant agents potentiated the inhibition
Rattus norvegicus
4.2.1.24
diphenyl diselenide
0.0005 mM, 17% inhibition
Rattus norvegicus
4.2.1.24
meso-2,3-dimercaptosuccinic acid
0.1 mM, 18% inhibition
Rattus norvegicus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
4.2.1.24
lung
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.24
5-aminolevulinate + 5-aminolevulinate
-
679181
Rattus norvegicus
porphobilinogen + 2 H2O
-
-
-
?