EC Number | Application | Comment | Organism |
---|---|---|---|
5.4.99.9 | analysis | high-throughput fluorescence polarization assay for indentification of inhibitors of enzyme and homologues | Klebsiella pneumoniae |
EC Number | Cloned (Comment) | Organism |
---|---|---|
5.4.99.9 | expression in Escherichia coli, His-tagged protein | Klebsiella pneumoniae |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
5.4.99.9 | (2Z)-2-(2-chloro-4-hydroxy-5-nitrobenzylidene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one | comparison with inhibition of Mycobacterium tuberculosis enzyme; dissociation constant 0.0053 mM, comparison with inhibition of Klebsiella pneumoniae enzyme | Klebsiella pneumoniae | |
5.4.99.9 | (4E)-4-(4-chloro-3-nitrobenzylidene)-1-(3,4-dichlorophenyl)pyrazolidine-3,5-dione | comparison with inhibition of Mycobacterium tuberculosis enzyme; dissociation constant 0.0049 mM, comparison with inhibition of Klebsiella pneumoniae enzyme | Klebsiella pneumoniae | |
5.4.99.9 | 2-(([2-(4-bromophenyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]carbonyl)amino)benzoic acid | comparison with inhibition of Mycobacterium tuberculosis enzyme | Klebsiella pneumoniae | |
5.4.99.9 | 2-[(5E)-5-(3-bromobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-3-phenylpropanoic acid | comparison with inhibition of Mycobacterium tuberculosis enzyme; dissociation constant 0.0094 mM, comparison with inhibition of Klebsiella pneumoniae enzyme | Klebsiella pneumoniae | |
5.4.99.9 | 2-[(5E)-5-(4-bromobenzylidene)-2-thioxo-1,3-thiazolidin-3-yl]-3-phenylpropanoic acid | dissociation constant 0.0093 mM, comparison with inhibition of Klebsiella pneumoniae enzyme | Klebsiella pneumoniae |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.4.99.9 | Klebsiella pneumoniae | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.4.99.9 | UDP-D-galactofuranose | - |
Klebsiella pneumoniae | UDP-D-galactopyranose | - |
r | |
5.4.99.9 | UDP-D-galactopyranose | - |
Klebsiella pneumoniae | UDP-D-galactofuranose | - |
r |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
5.4.99.9 | 0.0016 | - |
pH 7.0, 37°C | Klebsiella pneumoniae | 2-[(5E)-5-(3-bromobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-3-phenylpropanoic acid | |
5.4.99.9 | 0.004 | - |
pH 7.0, 37°C | Klebsiella pneumoniae | (4E)-4-(4-chloro-3-nitrobenzylidene)-1-(3,4-dichlorophenyl)pyrazolidine-3,5-dione | |
5.4.99.9 | 0.004 | - |
pH 7.0, 37°C | Klebsiella pneumoniae | (2Z)-2-(2-chloro-4-hydroxy-5-nitrobenzylidene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one | |
5.4.99.9 | 0.0046 | - |
pH 7.0, 37°C | Klebsiella pneumoniae | 2-(([2-(4-bromophenyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]carbonyl)amino)benzoic acid | |
5.4.99.9 | 0.035 | - |
pH 7.0, 37°C | Klebsiella pneumoniae | (2Z)-2-(2-chloro-4-hydroxy-5-nitrobenzylidene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one | |
5.4.99.9 | 0.041 | - |
pH 7.0, 37°C | Klebsiella pneumoniae | (4E)-4-(4-chloro-3-nitrobenzylidene)-1-(3,4-dichlorophenyl)pyrazolidine-3,5-dione | |
5.4.99.9 | 0.065 | - |
pH 7.0, 37°C | Klebsiella pneumoniae | 2-[(5E)-5-(3-bromobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-3-phenylpropanoic acid |