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Literature summary extracted from

  • Qin, Y.; Pang, J.Y.; Chen, W.H.; Zhao, Z.Z.; Liu, L.; Jiang, Z.H.
    Inhibition of DNA topoisomerase I by natural and synthetic mono- and dimeric protoberberine alkaloids (2007), Chem. Biodivers., 4, 481-487.
    View publication on PubMed

Application

EC Number Application Comment Organism
5.6.2.1 drug development dimeric compounds are promising candidates to be further elaborated as anticancer leads Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.2.1 10-methoxy-9-{2-[(2,9,10-trimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium-3-yl)oxy]ethoxy}[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium dichloride synthetic protoberberine alkaloid, highly active Homo sapiens
5.6.2.1 10-methoxy-9-{3-[(2,9,10-trimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium-3-yl)oxy]propoxy}[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium dichloride synthetic protoberberine alkaloid, highly active Homo sapiens
5.6.2.1 10-methoxy-9-{4-[(2,9,10-trimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium-3-yl)oxy]butoxy}[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium dichloride synthetic protoberberine alkaloid, highly active Homo sapiens
5.6.2.1 3,3'-[butane-1,4-diylbis(oxy)]bis(2,9,10-trimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium) dichloride synthetic protoberberine alkaloid, highly active Homo sapiens
5.6.2.1 3,3'-[ethane-1,2-diylbis(oxy)]bis(2,9,10-trimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium) dichloride synthetic protoberberine alkaloid, highly active. Strongly stabilize the enzyme-DNA binary complex at low concentration (50–100microM). From 0.1 to 1 mM, their ability to stabilize is weak Homo sapiens
5.6.2.1 3,3'-[propane-1,3-diylbis(oxy)]bis(2,9,10-trimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium) dichloride synthetic protoberberine alkaloid, highly active Homo sapiens
5.6.2.1 9,9'-[butane-1,4-diylbis(oxy)]bis(10-methoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium) dichloride synthetic protoberberine alkaloid, highly active Homo sapiens
5.6.2.1 9,9'-[ethane-1,2-diylbis(oxy)]bis(10-methoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium)dichloride synthetic protoberberine alkaloid, highly active Homo sapiens
5.6.2.1 9,9'-[heptane-1,7-diylbis(oxy)]bis(10-methoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium) dichloride synthetic protoberberine alkaloid, highly active Homo sapiens
5.6.2.1 9,9'-[hexane-1,6-diylbis(oxy)]bis(10-methoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium) dichloride synthetic protoberberine alkaloid, highly active Homo sapiens
5.6.2.1 9,9'-[pentane-1,5-diylbis(oxy)]bis(10-methoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium) dichloride synthetic protoberberine alkaloid, highly active Homo sapiens
5.6.2.1 9,9'-[propane-1,3-diylbis(oxy)]bis(10-methoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium) dichloride synthetic protoberberine alkaloid, highly active. Strongly stabilize the enzyme-DNA binary complex at low concentration (50–100microM). From 0.1 to 1 mM, their ability to stabilize is weak Homo sapiens
5.6.2.1 9-O-(2-aminoethyl)berberine synthetic protoberberine alkaloid Homo sapiens
5.6.2.1 9-O-(2-hydroxyethyl)berberine synthetic protoberberine alkaloid Homo sapiens
5.6.2.1 9-O-[2-(1H-imidazol-1-yl)ethyl]berberine synthetic protoberberine alkaloid Homo sapiens
5.6.2.1 9-O-[2-(4-methylpiperazin-1-yl)ethyl]berberine synthetic protoberberine alkaloid Homo sapiens
5.6.2.1 Berberine natural protoberberine alkaloid Homo sapiens
5.6.2.1 berberrubine natural protoberberine alkaloid Homo sapiens
5.6.2.1 camptothecin topoisomerase I poison Homo sapiens
5.6.2.1 coptisine natural protoberberine alkaloid Homo sapiens
5.6.2.1 Jatrorrhizine natural protoberberine alkaloid Homo sapiens
5.6.2.1 jatrorubine natural protoberberine alkaloid Homo sapiens
5.6.2.1 additional information series of natural and synthetic protoberberine alkaloid evaluated for their inhibitory activities towards DNA topoisomerase I. Natural, monomeric protoberberine alkaloids and their mono-modified congeners show only minor activities. Most of the dimeric protoberberine alkaloids are highly active Homo sapiens
5.6.2.1 palmatine natural protoberberine alkaloid Homo sapiens
5.6.2.1 palmatrubine natural protoberberine alkaloid Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
5.6.2.1 Homo sapiens
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-
-

Synonyms

EC Number Synonyms Comment Organism
5.6.2.1 DNA topoisomerase I
-
 Homo sapiens
5.6.2.1 Topoisomerase I
-
 Homo sapiens