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Literature summary extracted from

  • Ion, G.; Fajka-Boja, R.; Kovacs, F.; Szebeni, G.; Gombos, I.; Czibula, A.; Matko, J.; Monostori, E.
    Acid sphingomyelinase mediated release of ceramide is essential to trigger the mitochondrial pathway of apoptosis by galectin-1 (2006), Cell. Signal., 18, 1887-1896.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.12 galectin-I human, induces apoptosis and initiates the acid SMase-mediated release of ceramide Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.12 plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 sphingomyelin + H2O Homo sapiens the enzyme is involved in ceramide signaling, enzyme regulation and ceramide metabolism with galectin-I signaling, overview N-acylsphingosine + choline phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 I 9.2 cell a Jurkat cell line derivative lacking caspase 8 Homo sapiens
-
3.1.4.12 JURKAT cell different variants Homo sapiens
-
3.1.4.12 T-lymphocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 sphingomyelin + H2O
-
 Homo sapiens N-acylsphingosine + choline phosphate
-
 ?
3.1.4.12 sphingomyelin + H2O the enzyme is involved in ceramide signaling, enzyme regulation and ceramide metabolism with galectin-I signaling, overview Homo sapiens N-acylsphingosine + choline phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 acid sphingomyelinase
-
 Homo sapiens