Literature summary extracted from

Schulte, M.; Reiss, K.; Lettau, M.; Maretzky, T.; Ludwig, A.; Hartmann, D.; de Strooper, B.; Janssen, O.; Saftig, P.
ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death (2007), Cell Death Differ., 14, 1040-1049.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.4.24.81	expressed in MEF cells and 293-T cells	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.24.81	AEBSF	0.1 mM	Homo sapiens
3.4.24.81	GI254023X	0.005 mM	Homo sapiens
3.4.24.81	GM6001	0.01 mM	Homo sapiens
3.4.24.81	GW280264X	0.005 mM	Homo sapiens
3.4.24.81	pepstatin A	0.001 mM	Homo sapiens
3.4.24.81	TNFalpha protease inhibitor	0.05 mM	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.24.81	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.24.81	Fas ligand + H2O	transmembrane protein	Homo sapiens	soluble Fas ligand ectodomain + ?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.24.81	a disintegrin and metalloproteinase 10	-	Homo sapiens
3.4.24.81	ADAM10	-	Homo sapiens

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Release 2023.1 (January 2023)