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Literature summary extracted from

  • Muehlbauer, S.M.; Evering, T.H.; Bonuccelli, G.; Squires, R.C.; Ashton, A.W.; Porcelli, S.A.; Lisanti, M.P.; Brojatsch, J.
    Anthrax lethal toxin kills macrophages in a strain-specific manner by apoptosis or caspase-1-mediated necrosis (2007), Cell Cycle, 6, 758-766.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.36 acetyl-Tyr-Val-Ala-Asp-chloromethylketone
-
 Mus musculus
3.4.22.36 benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone
-
 Mus musculus
3.4.22.36 butyloxycarbonyl-Asp-chloromethylketone
-
 Mus musculus
3.4.22.36 butyloxycarbonyl-Asp-fluoromethylketone
-
 Mus musculus
3.4.24.83 additional information complete caspase-1 inhibition is required to block antrax lethal toxin-mediated necrosis Bacillus anthracis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.36 additional information Mus musculus caspase-1-mediated macrophage necrosis is the source of the cytokine storm and rapid disease progression in anthrax lethal toxin-treated BALB/c mice ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.36 Mus musculus
-
-
-
3.4.24.83 Bacillus anthracis
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.36 macrophage caspase-1-mediated macrophage necrosis is the source of the cytokine storm and rapid disease progression in anthrax lethal toxin-treated BALB/c mice Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.36 additional information caspase-1-mediated macrophage necrosis is the source of the cytokine storm and rapid disease progression in anthrax lethal toxin-treated BALB/c mice Mus musculus ?
-
 ?
3.4.24.83 mitogen-activated protein kinase 3 + H2O
-
 Bacillus anthracis ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.83 anthrax lethal factor anthrax lethal factor is part of the bipartite anthrax lethal toxin Bacillus anthracis