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Literature summary extracted from

  • Randall, C.L.; Burkard, M.E.; Jallepalli, P.V.
    Polo kinase and cytokinesis initiation in Mammalian cells: harnessing the awesome power of chemical genetics (2007), Cell Cycle, 6, 1713-1717.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.11.21 medicine correlation between Plk1 overexpression in tumors and poor patient prognosis, Plk1 acts at multiple discrete steps throughout late G2 phase, mitosis, and cytokinesis, triggers activation of the Ect2-RhoA network Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.21 additional information both copies of the PLK1 locus deleted in telomerase-immortalized human retinal pigment epithelial cells, more than 90% knockdown of Plk1 does not cause any cell cycle impairment, PLK1-null cells arrest in mitosis with immature centrosomes and monopolar spindles. Plk1 function and cell viability can be reconstituted by expressing either wildtype Plk1 or an analog-sensitive variant, the analog-sensitive variant is inhibited by 3-MB-PP1 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.21 BI-2536 potential anti-cancer therapeutic agent, shows strong selectivity for Plk1 Homo sapiens
2.7.11.21 BTO-1
-
 Homo sapiens
2.7.11.21 additional information inhibited by Plk1-specific antibodies Homo sapiens
2.7.11.21 RNA RNA interference abrogates centrosome maturation, spindle bipolarization, and silencing of the spindle assembly checkpoint Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.21 kinetochore rapidly accumulates at kinetochores, appears to be partially released once all chromosomes are properly congressed at the metaphase plate Homo sapiens 776
-
2.7.11.21 microtubule at anaphase onset, Plk1 redistributes onto equatorial microtubule bundles that define the spindle midzone or central spindle, and remain tightly associated with these microtubules during midbody formation and completion of cytokinesis Homo sapiens 5874
-
2.7.11.21 spindle rapidly accumulates at spindle poles Homo sapiens 5819
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.21 Homo sapiens P53350
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.21 carcinoma cell increased requirement for Plk1 in comparison to normal cells Homo sapiens
-
2.7.11.21 mitotic cell Plk1 abundance and kinase activity are strongly upregulated at the G2/M transition, reach a peak during mitosis, and are downregulated by the subsequent G1 phase, albeit with slower kinetics than Cdk1/cyclin B activity, which falls acutely at anaphase onset Homo sapiens
-
2.7.11.21 retinal pigment epithelium
-
 Homo sapiens
-
2.7.11.21 somatic cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.21 ATP + Ect2
-
 Homo sapiens ADP + phosphorylated Ect2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.21 Plk1
-
 Homo sapiens
2.7.11.21 Polo-like kinase 1
-
 Homo sapiens