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Literature summary extracted from

  • De Tullio, L.; Maggio, B.; Hartel, S.; Jara, J.; Fanani, M.L.
    The initial surface composition and topography modulate sphingomyelinase-driven sphingomyelin to ceramide conversion in lipid monolayers (2007), Cell Biochem. Biophys., 47, 169-177.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.12 ceramide feedback inhibition Bacillus cereus
3.1.4.12 palmitate a non-substrate lipid belonging to the phospholipase A2 pathway Bacillus cereus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.12 additional information
-
 additional information different SMase kinetic steps are differentially regulated by non-substrate lipids, overview Bacillus cereus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.12 extracellular
-
 Bacillus cereus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.12 Ca2+ plays a role in enzyme regulation by non-substrate lipids Bacillus cereus
3.1.4.12 Mg2+ dependent on, best at 3 mM Bacillus cereus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 sphingomyelin + H2O Bacillus cereus changes in the initial composition and topography of mixed monolayers of sphingomyelin and ceramide modulate the sphingomyelin degradation by the enzyme, overview, the enzyme in an extracellular toxin that exhibits potent hemolytic activity against sphingomyelin-rich erythrocytes in mammals N-acylsphingosine + choline phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Bacillus cereus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 commercial preparation
-
 Bacillus cereus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 sphingomyelin + H2O changes in the initial composition and topography of mixed monolayers of sphingomyelin and ceramide modulate the sphingomyelin degradation by the enzyme, overview, the enzyme in an extracellular toxin that exhibits potent hemolytic activity against sphingomyelin-rich erythrocytes in mammals Bacillus cereus N-acylsphingosine + choline phosphate
-
 ?
3.1.4.12 sphingomyelin + H2O SMase shows very low activity against condensed sphingomyelin, but is active on loosely organized sphingomyelin in bilayers and monolayers, overview Bacillus cereus N-acylsphingosine + choline phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.4.12 More the enzyme structure and topology influences the enzyme activity, overview Bacillus cereus

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 neutral SMase
-
 Bacillus cereus
3.1.4.12 SMase
-
 Bacillus cereus
3.1.4.12 sphingomyelinase
-
 Bacillus cereus