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Literature summary extracted from
- Synthesis of 2-deoxy-2-fluoro and 1,2-ene derivatives of the naturally occurring glycosidase inhibitor, salacinol, and their inhibitory activities against recombinant human maltase glucoamylase (2008), Carbohydr. Res., 343, 951-956.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.2.1.3 | 2-deoxy-1-ene-salacinol | synthesis, overview | Homo sapiens |  |
| 3.2.1.3 | 2-deoxy-2-fluorosalacinol | synthesis, overview | Homo sapiens | |
| 3.2.1.3 | salacinol | a naturally occurring glycosidase inhibitor isolated from roots and stems of a Sri Lankan plant, Salacia reticulata, the OH group on C-2 of salacinol is critical as a hydrogen-bond donor with functional groups in the active site of the enzyme | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.2.1.3 | additional information | Homo sapiens | key intestinal enzymes involved in the breakdown of glucose | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.2.1.3 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.2.1.3 | intestine | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.2.1.3 | 4-nitrophenyl beta-D-glucoside + H2O | - |
Homo sapiens | 4-nitrophenol + beta-D-glucose | - |
? | |
| 3.2.1.3 | additional information | key intestinal enzymes involved in the breakdown of glucose | Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.2.1.3 | maltase glucoamylase | - |
Homo sapiens |
| 3.2.1.3 | MGA | - |
Homo sapiens |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.2.1.3 | 0.0002 | - |
salacinol | - |
Homo sapiens | |
| 3.2.1.3 | 0.006 | - |
2-deoxy-2-fluorosalacinol | - |
Homo sapiens | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.2.1.3 | 0.15 | - |
- |
Homo sapiens | 2-deoxy-1-ene-salacinol | |
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