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Literature summary extracted from

  • Murthy, K.S.
    Contractile agonists attenuate cGMP levels by stimulating phosphorylation of cGMP-specific PDE5; an effect mediated by RhoA/PKC-dependent inhibition of protein phosphatase 1 (2008), Br. J. Pharmacol., 2008, 1-11.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.35 S-nitrosoglutathione stimulation of isoform PDE5 phosphorylation and activity, resulting in increased levels of cGMP in gastric smooth muscle cells. Concurrent activation of cells with acetylcholine augments stimulation and attenuates cGMP levels Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.35 Oryctolagus cuniculus
-
 isoform PDE5
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.4.35 phosphoprotein activation of isoform PDE5 by phosphorylation. PDE5 is dephosphorylated by the catalytic subunit of protein phosphatase 1 but not protein phosphatase 2A Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.35 stomach
-
 Oryctolagus cuniculus
-

Subunits

EC Number Subunits Comment Organism
3.1.4.35 More isoform PDE5 is associated with protein phosphatase 1 Oryctolagus cuniculus