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Literature summary extracted from
- Altered collecting duct adenylyl cyclase content in collecting duct endothelin-1 knockout mice (2007), BMC Nephrol., 8, 8.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.6.1.1 | cholera toxin | - |
Mus musculus | |
| 4.6.1.1 | forskolin | - |
Mus musculus |  |
| 4.6.1.1 | pertussis toxin | - |
Mus musculus | |
| 4.6.1.1 | Vasopressin | causes halfmaximal stimulation of cAMP accumulation | Mus musculus | |
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 4.6.1.1 | additional information | endothelin-1 deficiency increases inner medullary collecting duct AC5/6 content, that may synergize with acute endothelin-1 inhibition of vasopressin-stimulated cAMP accumulation | Mus musculus |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 4.6.1.1 | additional information | mice with collecting duct-specific deletion of endothelin-1, mRNA or protein levels of AC3 not affected, increased protein levels of AC5/6, AC5 and AC6 mRNA levels are unchanged, show enhanced vasopressin-stimulated cAMP accumulation | Mus musculus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.6.1.1 | BAPTA | inhibits calcium-stimulated AC | Mus musculus | |
| 4.6.1.1 | additional information | inhibition of NO, superoxide and or prostaglandin formation does not affect vasopressin-stimulated cAMP accumulation | Mus musculus |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.6.1.1 | Ca2+ | - |
Mus musculus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.6.1.1 | Mus musculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.6.1.1 | additional information | primarily expresses AC3 mRNA in the inner medullary collecting duct, AC5 and AC6 also present | Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.6.1.1 | ATP | - |
Mus musculus | 3',5'-cAMP + diphosphate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.6.1.1 | AC3 | - |
Mus musculus |
| 4.6.1.1 | AC5 | - |
Mus musculus |
| 4.6.1.1 | AC6 | - |
Mus musculus |
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Release 2023.1 (January 2023)
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