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Literature summary extracted from

  • de Paolis, F.; Beghetto, E.; Spadoni, A.; Montagnani, F.; Felici, F.; Oggioni, M.R.; Gargano, N.
    Identification of a human immunodominant B-cell epitope within the immunoglobulin A1 protease of Streptococcus pneumoniae (2007), BMC Microbiol., 7, 113.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.4.24.13 medicine the broad and specific recognition of the epiA polypeptide by human sera demonstrate that the pneumococcal IgA1 protease contains an immunodominant B-cell epitope Streptococcus pneumoniae

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.13 additional information an antigenic sequence corresponding to amino acids 420-457 (epiA) of the iga gene product is identified by screening a pneumococcal phage display library with patient's sera. The epiA peptide is conserved in all pneumococci and in two out of three Sreptococcus mitis strains. This epitope is specifically recognized by antibodies present in sera from 90% of healthy adults, thus representing an important target of the humoral response to Streptococcus pneumoniae and Streptococcus mitis infection Streptococcus pneumoniae

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.13 Streptococcus pneumoniae
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Source Tissue

EC Number Source Tissue Comment Organism Textmining

Synonyms

EC Number Synonyms Comment Organism
3.4.24.13 IgA1 protease
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 Streptococcus pneumoniae