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Literature summary extracted from

  • Lindahl, A.L.; Olsson, M.E.; Mercke, P.; Tollbom, O.; Schelin, J.; Brodelius, M.; Brodelius, P.E.
    Production of the artemisinin precursor amorpha-4,11-diene by engineered Saccharomyces cerevisiae (2006), Biotechnol. Lett., 28, 571-580.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.2.3.24 medicine amorpha-4,11-diene is a presursor of artemisinin, artemisinin and derivates are used for the treatment of malaria Artemisia annua

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.3.24 into the pYeDP60 vector for expression in Saccharomyces cerevisiae, and, in addition, introduced into the yeast genome by homologous recombination Artemisia annua

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.3.24 2-trans,6-trans-farnesyl diphosphate Artemisia annua
-
 amorpha-4,11-diene + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.3.24 Artemisia annua Q9AR04
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.3.24 2-trans,6-trans-farnesyl diphosphate
-
 Artemisia annua amorpha-4,11-diene + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.3.24 ADS
-
 Artemisia annua
4.2.3.24 amorpha-4,11-diene synthase
-
 Artemisia annua