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Literature summary extracted from

  • Hari Babu, T.; Rama Subba Rao, V.; Tiwari, A.K.; Suresh Babu, K.; Srinivas, P.V.; Ali, A.Z.; Madhusudana Rao, J.
    Synthesis and biological evaluation of novel 8-aminomethylated oroxylin A analogues as alpha-glucosidase inhibitors (2008), Bioorg. Med. Chem. Lett., 18, 1659-1662.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.20 (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol
-
 Saccharomyces cerevisiae
3.2.1.20 5,7-dihydroxy-2-phenyl-4H-chromen-4-one from hexane extracts of the Indian herb Oroxylum indicum Saccharomyces cerevisiae
3.2.1.20 5,7-dihydroxy-6-methoxy-2-phenyl-8-(piperidin-1-ylmethyl)-4H-chromen-4-one
-
 Rattus norvegicus
3.2.1.20 5,7-dihydroxy-6-methoxy-2-phenyl-8-(piperidin-1-ylmethyl)-4H-chromen-4-one
-
 Saccharomyces cerevisiae
3.2.1.20 5,7-dihydroxy-6-methoxy-8-(morpholin-4-ylmethyl)-2-phenyl-4H-chromen-4-one
-
 Rattus norvegicus
3.2.1.20 5,7-dihydroxy-6-methoxy-8-(morpholin-4-ylmethyl)-2-phenyl-4H-chromen-4-one
-
 Saccharomyces cerevisiae
3.2.1.20 5,7-dihydroxy-6-methoxy-8-[(4-methylpiperazin-1-yl)methyl]-2-phenyl-4H-chromen-4-one
-
 Rattus norvegicus
3.2.1.20 5,7-dihydroxy-6-methoxy-8-[(4-methylpiperazin-1-yl)methyl]-2-phenyl-4H-chromen-4-one
-
 Saccharomyces cerevisiae
3.2.1.20 acarbose
-
 Rattus norvegicus
3.2.1.20 baicalein i.e. 5,6,7-trihydroxy flavone, from hexane extracts of the Indian herb Oroxylum indicum Rattus norvegicus
3.2.1.20 baicalein i.e. 5,6,7-trihydroxy flavone, from hexane extracts of the Indian herb Oroxylum indicum Saccharomyces cerevisiae
3.2.1.20 chrysin from hexane extracts of the Indian herb Oroxylum indicum Rattus norvegicus
3.2.1.20 additional information no inhibition by acarbose Saccharomyces cerevisiae
3.2.1.20 oroxylin A from hexane extracts of the Indian herb Oroxylum indicum Rattus norvegicus
3.2.1.20 oroxylin A from hexane extracts of the Indian herb Oroxylum indicum Saccharomyces cerevisiae
3.2.1.20 tert-butyl 4-[(5,7-dihydroxy-6-methoxy-4-oxo-2-phenyl-4H-chromen-8-yl)methyl]piperazine-1-carboxylate
-
 Rattus norvegicus
3.2.1.20 tert-butyl 4-[(5,7-dihydroxy-6-methoxy-4-oxo-2-phenyl-4H-chromen-8-yl)methyl]piperazine-1-carboxylate
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.20 maltose + H2O Rattus norvegicus
-
 alpha-D-glucose + D-glucose
-
 ?
3.2.1.20 maltose + H2O Saccharomyces cerevisiae
-
 alpha-D-glucose + D-glucose
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.20 Rattus norvegicus
-
-
-
3.2.1.20 Saccharomyces cerevisiae
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.20 intestine
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.20 4-nitrophenyl alpha-D-glucopyranoside + H2O
-
 Rattus norvegicus 4-nitrophenol + alpha-D-glucose
-
 ?
3.2.1.20 4-nitrophenyl alpha-D-glucopyranoside + H2O
-
 Saccharomyces cerevisiae 4-nitrophenol + alpha-D-glucose
-
 ?
3.2.1.20 maltose + H2O
-
 Rattus norvegicus alpha-D-glucose + D-glucose
-
 ?
3.2.1.20 maltose + H2O
-
 Saccharomyces cerevisiae alpha-D-glucose + D-glucose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.20 maltase
-
 Rattus norvegicus
3.2.1.20 maltase
-
 Saccharomyces cerevisiae

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.2.1.20 0.5
-
 baicalein
-
 Rattus norvegicus
3.2.1.20 0.5
-
 baicalein
-
 Saccharomyces cerevisiae

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.2.1.20 0.0064
-
-
 Rattus norvegicus acarbose
3.2.1.20 0.0354
-
-
 Rattus norvegicus 5,7-dihydroxy-6-methoxy-8-[(4-methylpiperazin-1-yl)methyl]-2-phenyl-4H-chromen-4-one
3.2.1.20 0.0493
-
-
 Saccharomyces cerevisiae (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol
3.2.1.20 0.0507
-
-
 Rattus norvegicus 5,7-dihydroxy-6-methoxy-2-phenyl-8-(piperidin-1-ylmethyl)-4H-chromen-4-one
3.2.1.20 0.075
-
-
 Rattus norvegicus tert-butyl 4-[(5,7-dihydroxy-6-methoxy-4-oxo-2-phenyl-4H-chromen-8-yl)methyl]piperazine-1-carboxylate
3.2.1.20 0.076
-
-
 Rattus norvegicus 5,7-dihydroxy-6-methoxy-8-(morpholin-4-ylmethyl)-2-phenyl-4H-chromen-4-one
3.2.1.20 0.08 4
-
 Saccharomyces cerevisiae tert-butyl 4-[(5,7-dihydroxy-6-methoxy-4-oxo-2-phenyl-4H-chromen-8-yl)methyl]piperazine-1-carboxylate
3.2.1.20 0.099
-
-
 Saccharomyces cerevisiae 5,7-dihydroxy-6-methoxy-8-[(4-methylpiperazin-1-yl)methyl]-2-phenyl-4H-chromen-4-one
3.2.1.20 0.124
-
-
 Saccharomyces cerevisiae oroxylin A
3.2.1.20 0.135
-
-
 Rattus norvegicus oroxylin A
3.2.1.20 0.15
-
-
 Saccharomyces cerevisiae 5,7-dihydroxy-6-methoxy-8-(morpholin-4-ylmethyl)-2-phenyl-4H-chromen-4-one
3.2.1.20 0.167
-
-
 Saccharomyces cerevisiae 5,7-dihydroxy-6-methoxy-2-phenyl-8-(piperidin-1-ylmethyl)-4H-chromen-4-one
3.2.1.20 0.203
-
-
 Saccharomyces cerevisiae baicalein
3.2.1.20 0.214
-
-
 Rattus norvegicus baicalein
3.2.1.20 0.371
-
-
 Saccharomyces cerevisiae 5,7-dihydroxy-2-phenyl-4H-chromen-4-one
3.2.1.20 0.375
-
-
 Rattus norvegicus chrysin