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Literature summary extracted from

  • Gaddis, B.D.; Avramova, L.V.; Chmielewski, J.
    Inhibitors of anthrax lethal factor (2007), Bioorg. Med. Chem. Lett., 17, 4575-4578.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.83 (9E)-N-[2-(2,4,5-trihydroxyphenyl)ethyl]octadec-9-enamide
-
 Bacillus anthracis
3.4.24.83 (9E)-N-[2-(3,4,5-trihydroxyphenyl)ethyl]octadec-9-enamide
-
 Bacillus anthracis
3.4.24.83 N-hydroxy-4-[2-[(9E)-octadec-9-enoylamino]ethyl]benzamide
-
 Bacillus anthracis
3.4.24.83 N-oleoyldopamine uncompetitive inhibition Bacillus anthracis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.83 Zn2+ dependent Bacillus anthracis

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.83 Bacillus anthracis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.83 mitogen-activated protein kinase + H2O
-
 Bacillus anthracis ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.83 anthrax lethal factor
-
 Bacillus anthracis
3.4.24.83 LeTx
-
 Bacillus anthracis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.24.83 0.0017
-
 (9E)-N-[2-(3,4,5-trihydroxyphenyl)ethyl]octadec-9-enamide
-
 Bacillus anthracis
3.4.24.83 0.003
-
 N-oleoyldopamine
-
 Bacillus anthracis
3.4.24.83 0.06
-
 N-hydroxy-4-[2-[(9E)-octadec-9-enoylamino]ethyl]benzamide
-
 Bacillus anthracis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.24.83 0.013
-
-
 Bacillus anthracis (9E)-N-[2-(3,4,5-trihydroxyphenyl)ethyl]octadec-9-enamide
3.4.24.83 0.015
-
-
 Bacillus anthracis N-oleoyldopamine
3.4.24.83 0.032
-
-
 Bacillus anthracis N-hydroxy-4-[2-[(9E)-octadec-9-enoylamino]ethyl]benzamide
3.4.24.83 0.07
-
-
 Bacillus anthracis (9E)-N-[2-(2,4,5-trihydroxyphenyl)ethyl]octadec-9-enamide