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Literature summary extracted from

  • Cai, S.; Li, Q.S.; Borchardt, R.T.; Kuczera, K.; Schowen, R.L.
    The antiviral drug ribavirin is a selective inhibitor of S-adenosyl-L-homocysteine hydrolase from Trypanosoma cruzi (2007), Bioorg. Med. Chem., 15, 7281-7287.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.13.2.1 expression in Escherichia coli Homo sapiens
3.13.2.1 expression in Escherichia coli Trypanosoma cruzi

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.13.2.1 ribavirin binds to adenosine-binding site of enzyme and reduces the NAD+ cofactor to NADH. Selective for trypanosomal enzyme over human enzyme, as the slow inactivation step is 5fold faster with the trypanosomal enzyme Homo sapiens
3.13.2.1 ribavirin binds to adenosine-binding site of enzyme and reduces the NAD+ cofactor to NADH. Selective for trypanosomal enzyme over human enzyme, as the slow inactivation step is 5fold faster with the trypanosomal enzyme Trypanosoma cruzi

Organism

EC Number Organism UniProt Comment Textmining
3.13.2.1 Homo sapiens
-
-
-
3.13.2.1 Trypanosoma cruzi
-
-
-

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.13.2.1 0.194
-
 ribavirin pH 7.2, 22°C Trypanosoma cruzi
3.13.2.1 0.266
-
 ribavirin pH 7.2, 22°C Homo sapiens