BRENDA - Enzyme Database show

Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides

Nishimori, I.; Minakuchi, T.; Onishi, S.; Vullo, D.; Cecchi, A.; Scozzafava, A.; Supuran, C.T.; Bioorg. Med. Chem. 15, 7229-7236 (2007)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
4.2.1.1
expression in Escherichia coli
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
4.2.1.1
2-aminobenzenesulfonamide
-
Homo sapiens
4.2.1.1
2-hydrazinobenzenesulfonamide
-
Homo sapiens
4.2.1.1
4-(2-aminoethyl)benzenesulfonamide
-
Homo sapiens
4.2.1.1
4-(2-hydroxyethyl)benzenesulfonamide
-
Homo sapiens
4.2.1.1
4-(aminomethyl)benzenesulfonamide
-
Homo sapiens
4.2.1.1
4-(aminosulfonyl)-N-{2-[4-(aminosulfonyl)phenyl]ethyl}benzamide
-
Homo sapiens
4.2.1.1
4-(aminosulfonyl)benzoic acid
-
Homo sapiens
4.2.1.1
4-(hydroxymethyl)benzenesulfonamide
-
Homo sapiens
4.2.1.1
4-amino-3,5-dibromobenzenesulfonamide
-
Homo sapiens
4.2.1.1
4-amino-3-chlorobenzenesulfonamide
-
Homo sapiens
4.2.1.1
4-amino-3-fluoro-5-iodobenzenesulfonamide
-
Homo sapiens
4.2.1.1
4-amino-3-fluorobenzenesulfonamide
-
Homo sapiens
4.2.1.1
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
-
Homo sapiens
4.2.1.1
4-amino-6-chlorobenzene-1,3-disulfonamide
-
Homo sapiens
4.2.1.1
4-amino-N-[4-(aminosulfonyl)benzyl]benzenesulfonamide
-
Homo sapiens
4.2.1.1
4-amino-N-{2-[4-(aminosulfonyl)phenyl]ethyl}benzenesulfonamide
-
Homo sapiens
4.2.1.1
4-Aminobenzenesulfonamide
-
Homo sapiens
4.2.1.1
4-methylbenzenesulfonamide
-
Homo sapiens
4.2.1.1
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
-
Homo sapiens
4.2.1.1
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
-
Homo sapiens
4.2.1.1
5-acetamido-1,3,4-thiadiazole-2-sulfonamide
-
Homo sapiens
4.2.1.1
5-amino-1,3,4-thiadiazole-2-sulfonamide
-
Homo sapiens
4.2.1.1
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
Homo sapiens
4.2.1.1
5-{[(4-amino-3-chloro-5-fluorophenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
Homo sapiens
4.2.1.1
5-{[(4-aminophenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
Homo sapiens
4.2.1.1
benzolamide
-
Homo sapiens
4.2.1.1
brinzolamide
-
Homo sapiens
4.2.1.1
celecoxib
-
Homo sapiens
4.2.1.1
dichlorophenamide
-
Homo sapiens
4.2.1.1
dorzolamide
-
Homo sapiens
4.2.1.1
ethoxzolamide
-
Homo sapiens
4.2.1.1
methazolamide
-
Homo sapiens
4.2.1.1
prontosil
-
Homo sapiens
4.2.1.1
saccharin
-
Homo sapiens
4.2.1.1
sulpiride
-
Homo sapiens
4.2.1.1
topiramate
-
Homo sapiens
4.2.1.1
valdecoxib
-
Homo sapiens
4.2.1.1
zonisamide
-
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
4.2.1.1
cytosol
-
Homo sapiens
5829
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.2.1.1
Homo sapiens
P07451
-
-
Purification (Commentary)
EC Number
Commentary
Organism
4.2.1.1
-
Homo sapiens
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
4.2.1.1
pancreas
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.1
CO2 + H2O
-
678614
Homo sapiens
H2CO3
-
-
-
?
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
4.2.1.1
0.0079
-
4-methylbenzenesulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.0097
-
4-amino-6-chlorobenzene-1,3-disulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.0104
-
sulpiride
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.0106
-
topiramate
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.0107
-
4-amino-3,5-dibromobenzenesulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.0113
-
4-(aminosulfonyl)benzoic acid
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.0143
-
benzolamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.0146
-
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.0181
-
5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.019
-
4-amino-3-fluoro-5-iodobenzenesulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.0805
-
5-[[(4-amino-3-chloro-5-fluorophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.11
-
brinzolamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.114
-
4-amino-N-[4-(aminosulfonyl)benzyl]benzenesulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.14
-
4-amino-N-[2-[4-(aminosulfonyl)phenyl]ethyl]benzenesulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.148
-
5-amino-1,3,4-thiadiazole-2-sulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.154
-
valdecoxib
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.198
-
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.236
-
5-acetamido-1,3,4-thiadiazole-2-sulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.681
-
4-(aminomethyl)benzenesulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.684
-
dichlorophenamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.71
-
4-amino-3-chlorobenzenesulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.77
-
dorzolamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.77
-
methazolamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.78
-
zonisamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.788
-
prontosil
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.887
-
2-aminobenzenesulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.988
-
4-Aminobenzenesulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
1
-
celecoxib
20°C, pH 7.5
Homo sapiens
4.2.1.1
1.06
-
4-(aminosulfonyl)-N-[2-[4-(aminosulfonyl)phenyl]ethyl]benzamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
1.113
-
ethoxzolamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
1.187
-
4-(2-hydroxyethyl)benzenesulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
1.276
-
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
1.6
-
4-(2-aminoethyl)benzenesulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
1.995
-
2-hydrazinobenzenesulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
2.075
-
4-amino-3-fluorobenzenesulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
2.2
-
saccharin
20°C, pH 7.5
Homo sapiens
4.2.1.1
2.633
-
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
4.89
-
4-(hydroxymethyl)benzenesulfonamide
20°C, pH 7.5
Homo sapiens
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
4.2.1.1
expression in Escherichia coli
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
4.2.1.1
2-aminobenzenesulfonamide
-
Homo sapiens
4.2.1.1
2-hydrazinobenzenesulfonamide
-
Homo sapiens
4.2.1.1
4-(2-aminoethyl)benzenesulfonamide
-
Homo sapiens
4.2.1.1
4-(2-hydroxyethyl)benzenesulfonamide
-
Homo sapiens
4.2.1.1
4-(aminomethyl)benzenesulfonamide
-
Homo sapiens
4.2.1.1
4-(aminosulfonyl)-N-{2-[4-(aminosulfonyl)phenyl]ethyl}benzamide
-
Homo sapiens
4.2.1.1
4-(aminosulfonyl)benzoic acid
-
Homo sapiens
4.2.1.1
4-(hydroxymethyl)benzenesulfonamide
-
Homo sapiens
4.2.1.1
4-amino-3,5-dibromobenzenesulfonamide
-
Homo sapiens
4.2.1.1
4-amino-3-chlorobenzenesulfonamide
-
Homo sapiens
4.2.1.1
4-amino-3-fluoro-5-iodobenzenesulfonamide
-
Homo sapiens
4.2.1.1
4-amino-3-fluorobenzenesulfonamide
-
Homo sapiens
4.2.1.1
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
-
Homo sapiens
4.2.1.1
4-amino-6-chlorobenzene-1,3-disulfonamide
-
Homo sapiens
4.2.1.1
4-amino-N-[4-(aminosulfonyl)benzyl]benzenesulfonamide
-
Homo sapiens
4.2.1.1
4-amino-N-{2-[4-(aminosulfonyl)phenyl]ethyl}benzenesulfonamide
-
Homo sapiens
4.2.1.1
4-Aminobenzenesulfonamide
-
Homo sapiens
4.2.1.1
4-methylbenzenesulfonamide
-
Homo sapiens
4.2.1.1
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
-
Homo sapiens
4.2.1.1
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
-
Homo sapiens
4.2.1.1
5-acetamido-1,3,4-thiadiazole-2-sulfonamide
-
Homo sapiens
4.2.1.1
5-amino-1,3,4-thiadiazole-2-sulfonamide
-
Homo sapiens
4.2.1.1
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
Homo sapiens
4.2.1.1
5-{[(4-amino-3-chloro-5-fluorophenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
Homo sapiens
4.2.1.1
5-{[(4-aminophenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
Homo sapiens
4.2.1.1
benzolamide
-
Homo sapiens
4.2.1.1
brinzolamide
-
Homo sapiens
4.2.1.1
celecoxib
-
Homo sapiens
4.2.1.1
dichlorophenamide
-
Homo sapiens
4.2.1.1
dorzolamide
-
Homo sapiens
4.2.1.1
ethoxzolamide
-
Homo sapiens
4.2.1.1
methazolamide
-
Homo sapiens
4.2.1.1
prontosil
-
Homo sapiens
4.2.1.1
saccharin
-
Homo sapiens
4.2.1.1
sulpiride
-
Homo sapiens
4.2.1.1
topiramate
-
Homo sapiens
4.2.1.1
valdecoxib
-
Homo sapiens
4.2.1.1
zonisamide
-
Homo sapiens
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
4.2.1.1
0.0079
-
4-methylbenzenesulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.0097
-
4-amino-6-chlorobenzene-1,3-disulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.0104
-
sulpiride
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.0106
-
topiramate
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.0107
-
4-amino-3,5-dibromobenzenesulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.0113
-
4-(aminosulfonyl)benzoic acid
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.0143
-
benzolamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.0146
-
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.0181
-
5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.019
-
4-amino-3-fluoro-5-iodobenzenesulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.0805
-
5-[[(4-amino-3-chloro-5-fluorophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.11
-
brinzolamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.114
-
4-amino-N-[4-(aminosulfonyl)benzyl]benzenesulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.14
-
4-amino-N-[2-[4-(aminosulfonyl)phenyl]ethyl]benzenesulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.148
-
5-amino-1,3,4-thiadiazole-2-sulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.154
-
valdecoxib
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.198
-
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.236
-
5-acetamido-1,3,4-thiadiazole-2-sulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.681
-
4-(aminomethyl)benzenesulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.684
-
dichlorophenamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.71
-
4-amino-3-chlorobenzenesulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.77
-
dorzolamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.77
-
methazolamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.78
-
zonisamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.788
-
prontosil
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.887
-
2-aminobenzenesulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
0.988
-
4-Aminobenzenesulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
1
-
celecoxib
20°C, pH 7.5
Homo sapiens
4.2.1.1
1.06
-
4-(aminosulfonyl)-N-[2-[4-(aminosulfonyl)phenyl]ethyl]benzamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
1.113
-
ethoxzolamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
1.187
-
4-(2-hydroxyethyl)benzenesulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
1.276
-
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
1.6
-
4-(2-aminoethyl)benzenesulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
1.995
-
2-hydrazinobenzenesulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
2.075
-
4-amino-3-fluorobenzenesulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
2.2
-
saccharin
20°C, pH 7.5
Homo sapiens
4.2.1.1
2.633
-
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
20°C, pH 7.5
Homo sapiens
4.2.1.1
4.89
-
4-(hydroxymethyl)benzenesulfonamide
20°C, pH 7.5
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
4.2.1.1
cytosol
-
Homo sapiens
5829
-
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
4.2.1.1
-
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
4.2.1.1
pancreas
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.1
CO2 + H2O
-
678614
Homo sapiens
H2CO3
-
-
-
?