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Literature summary extracted from
- Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones (2007), Bioorg. Med. Chem., 15, 575-585.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.7 | 3-[10-(benzylmethylamino)decyloxy]xanthen-9-one | - |
Homo sapiens |  |
| 3.1.1.7 | 3-[11-(benzylmethylamino)undecyloxy]xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.7 | 3-[12-(benzylmethylamino)dodecyloxy]xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.7 | 3-[3-(benzylmethylamino)propoxy]xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.7 | 3-[3-[(2-methoxybenzyl)methylamino]propoxy]-xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.7 | 3-[4-(benzylmethylamino)butoxy]xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.7 | 3-[5-(benzylmethylamino)pentyloxy]xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.7 | 3-[6-(benzylmethylamino)hexyloxy]xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.7 | 3-[7-(benzylmethylamino)-heptyloxy]xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.7 | 3-[7-(benzylmethylamino)heptyloxy]-6-methoxyxanthen-9-one | - |
Homo sapiens | |
| 3.1.1.7 | 3-[7-[(2,3-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.7 | 3-[7-[(2,5-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.7 | 3-[7-[(2-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.7 | 3-[7-[(2-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.7 | 3-[7-[(3-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.7 | 3-[7-[(3-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.7 | 3-[7-[(4-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.7 | 3-[7-[(4-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.7 | 3-[7-[ethyl-(2-methoxybenzyl)amino]heptyloxy]-xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.7 | 3-[7-[methyl-(2,3,4-trimethoxybenzyl)amino]-heptyloxy]xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.7 | 3-[7-[methyl-(2-methylbenzyl)amino]-heptyloxy]-xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.7 | 3-[7-[methyl-(2-nitrobenzyl)amino]heptyloxy]-xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.7 | 3-[8-(benzylmethylamino)octyloxy]xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.7 | 3-[9-(benzylmethylamino)nonyloxy]xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.7 | 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones | structure-activity relationships, overview | Homo sapiens | |
| 3.1.1.7 | 6-[7-(benzylmethylamino)heptyloxy]-2,3-dimethoxyxanthen-9-one | - |
Homo sapiens | |
| 3.1.1.7 | xanthostigmine | - |
Homo sapiens | |
| 3.1.1.8 | 3-[(methyl[7-[(9-oxo-9H-xanthen-3-yl)oxy]heptyl]amino)methyl]phenyl methylcarbamate | - |
Homo sapiens | |
| 3.1.1.8 | 3-[10-(benzylmethylamino)decyloxy]xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.8 | 3-[11-(benzylmethylamino)undecyloxy]xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.8 | 3-[12-(benzylmethylamino)dodecyloxy]xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.8 | 3-[3-(benzylmethylamino)propoxy]xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.8 | 3-[3-[(2-methoxybenzyl)methylamino]propoxy]-xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.8 | 3-[4-(benzylmethylamino)butoxy]xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.8 | 3-[5-(benzylmethylamino)pentyloxy]xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.8 | 3-[6-(benzylmethylamino)hexyloxy]xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.8 | 3-[7-(benzylmethylamino)-heptyloxy]xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.8 | 3-[7-(benzylmethylamino)heptyloxy]-6-methoxyxanthen-9-one | - |
Homo sapiens | |
| 3.1.1.8 | 3-[7-[(2,3-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.8 | 3-[7-[(2,5-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.8 | 3-[7-[(2-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.8 | 3-[7-[(2-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.8 | 3-[7-[(3-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.8 | 3-[7-[(3-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.8 | 3-[7-[(4-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.8 | 3-[7-[(4-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.8 | 3-[7-[ethyl-(2-methoxybenzyl)amino]heptyloxy]-xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.8 | 3-[7-[methyl-(2,3,4-trimethoxybenzyl)amino]-heptyloxy]xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.8 | 3-[7-[methyl-(2-methylbenzyl)amino]-heptyloxy]-xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.8 | 3-[7-[methyl-(2-nitrobenzyl)amino]heptyloxy]-xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.8 | 3-[8-(benzylmethylamino)octyloxy]xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.8 | 3-[9-(benzylmethylamino)nonyloxy]xanthen-9-one | - |
Homo sapiens | |
| 3.1.1.8 | 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones | structure-activity relationships, overview, inhibition with high selectivity toward BuChE | Homo sapiens | |
| 3.1.1.8 | 6-[7-(benzylmethylamino)heptyloxy]-2,3-dimethoxyxanthen-9-one | - |
Homo sapiens | |
| 3.1.1.8 | xanthostigmine | - |
Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.1.8 | extracellular | - |
Homo sapiens | - |
- |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.7 | Homo sapiens | - |
- |
- |
| 3.1.1.8 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.1.7 | commercial preparation | from erythrocytes | Homo sapiens | - |
| 3.1.1.7 | erythrocyte | - |
Homo sapiens | - |
| 3.1.1.8 | serum | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.7 | acetylthiocholine iodide + H2O | - |
Homo sapiens | thiocholine iodide + acetate | - |
? | |
| 3.1.1.8 | butyrylthiocholine + H2O | - |
Homo sapiens | thiocholine + butyrate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.1.7 | AChE | - |
Homo sapiens |
| 3.1.1.8 | BuChE | - |
Homo sapiens |
| 3.1.1.8 | butyrylcholinesterase | - |
Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.7 | 37 | - |
assay at | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.7 | 8 | - |
assay at | Homo sapiens |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.1.1.7 | 0.0003 | - |
- |
Homo sapiens | xanthostigmine | |
| 3.1.1.7 | 0.00218 | - |
pH 8.0, 37°C | Homo sapiens | 3-[7-[(2-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one | |
| 3.1.1.7 | 0.00232 | - |
pH 8.0, 37°C | Homo sapiens | 6-[7-(benzylmethylamino)heptyloxy]-2,3-dimethoxyxanthen-9-one | |
| 3.1.1.7 | 0.00268 | - |
pH 8.0, 37°C | Homo sapiens | 3-[3-(benzylmethylamino)propoxy]xanthen-9-one | |
| 3.1.1.7 | 0.00282 | - |
pH 8.0, 37°C | Homo sapiens | 3-[7-(benzylmethylamino)-heptyloxy]xanthen-9-one | |
| 3.1.1.7 | 0.00289 | - |
pH 8.0, 37°C | Homo sapiens | 3-[6-(benzylmethylamino)hexyloxy]xanthen-9-one | |
| 3.1.1.7 | 0.00315 | - |
pH 8.0, 37°C | Homo sapiens | 3-[7-[ethyl-(2-methoxybenzyl)amino]heptyloxy]-xanthen-9-one | |
| 3.1.1.7 | 0.0034 | - |
pH 8.0, 37°C | Homo sapiens | 3-[3-[(2-methoxybenzyl)methylamino]propoxy]-xanthen-9-one | |
| 3.1.1.7 | 0.00625 | - |
pH 8.0, 37°C | Homo sapiens | 3-[4-(benzylmethylamino)butoxy]xanthen-9-one | |
| 3.1.1.7 | 0.00778 | - |
pH 8.0, 37°C | Homo sapiens | 3-[5-(benzylmethylamino)pentyloxy]xanthen-9-one | |
| 3.1.1.7 | 0.00784 | - |
pH 8.0, 37°C | Homo sapiens | 3-[7-(benzylmethylamino)heptyloxy]-6-methoxyxanthen-9-one | |
| 3.1.1.7 | 0.0103 | - |
pH 8.0, 37°C | Homo sapiens | 3-[8-(benzylmethylamino)octyloxy]xanthen-9-one | |
| 3.1.1.7 | 0.04 | - |
pH 8.0, 37°C | Homo sapiens | 3-[7-[(3-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one | |
| 3.1.1.7 | 0.127 | - |
pH 8.0, 37°C | Homo sapiens | 3-[7-[(2,5-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one | |
| 3.1.1.7 | 0.138 | - |
pH 8.0, 37°C | Homo sapiens | 3-[7-[(2,3-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one | |
| 3.1.1.7 | 0.152 | - |
pH 8.0, 37°C | Homo sapiens | 3-[9-(benzylmethylamino)nonyloxy]xanthen-9-one | |
| 3.1.1.7 | 0.155 | - |
pH 8.0, 37°C | Homo sapiens | 3-[7-[methyl-(2,3,4-trimethoxybenzyl)amino]-heptyloxy]xanthen-9-one | |
| 3.1.1.7 | 0.36 | - |
pH 8.0, 37°C | Homo sapiens | 3-[7-[(4-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one | |
| 3.1.1.7 | 0.388 | - |
pH 8.0, 37°C | Homo sapiens | 3-[10-(benzylmethylamino)decyloxy]xanthen-9-one | |
| 3.1.1.7 | 0.413 | - |
pH 8.0, 37°C | Homo sapiens | 3-[7-[methyl-(2-nitrobenzyl)amino]heptyloxy]-xanthen-9-one | |
| 3.1.1.7 | 0.433 | - |
pH 8.0, 37°C | Homo sapiens | 3-[7-[(2-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one | |
| 3.1.1.7 | 0.565 | - |
pH 8.0, 37°C | Homo sapiens | 3-[7-[methyl-(2-methylbenzyl)amino]-heptyloxy]-xanthen-9-one | |
| 3.1.1.7 | 0.594 | - |
pH 8.0, 37°C | Homo sapiens | 3-[7-[(3-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one | |
| 3.1.1.7 | 0.626 | - |
pH 8.0, 37°C | Homo sapiens | 3-[11-(benzylmethylamino)undecyloxy]xanthen-9-one | |
| 3.1.1.7 | 0.908 | - |
pH 8.0, 37°C | Homo sapiens | 3-[12-(benzylmethylamino)dodecyloxy]xanthen-9-one | |
| 3.1.1.7 | 1.05 | - |
pH 8.0, 37°C | Homo sapiens | 3-[7-[(4-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one | |
| 3.1.1.8 | 0.00008 | - |
- |
Homo sapiens | 3-[8-(benzylmethylamino)octyloxy]xanthen-9-one | |
| 3.1.1.8 | 0.0001 | - |
- |
Homo sapiens | 3-[9-(benzylmethylamino)nonyloxy]xanthen-9-one | |
| 3.1.1.8 | 0.0001 | - |
- |
Homo sapiens | 3-[10-(benzylmethylamino)decyloxy]xanthen-9-one | |
| 3.1.1.8 | 0.00012 | - |
- |
Homo sapiens | 3-[11-(benzylmethylamino)undecyloxy]xanthen-9-one | |
| 3.1.1.8 | 0.00015 | - |
- |
Homo sapiens | 3-[12-(benzylmethylamino)dodecyloxy]xanthen-9-one | |
| 3.1.1.8 | 0.00032 | - |
- |
Homo sapiens | 3-[7-[ethyl-(2-methoxybenzyl)amino]heptyloxy]-xanthen-9-one | |
| 3.1.1.8 | 0.0008 | - |
- |
Homo sapiens | 3-[7-(benzylmethylamino)-heptyloxy]xanthen-9-one | |
| 3.1.1.8 | 0.00093 | - |
- |
Homo sapiens | 3-[7-[(2-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one | |
| 3.1.1.8 | 0.001 | - |
- |
Homo sapiens | 3-[7-[methyl-(2,3,4-trimethoxybenzyl)amino]-heptyloxy]xanthen-9-one | |
| 3.1.1.8 | 0.00127 | - |
- |
Homo sapiens | 3-[7-[(2,5-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one | |
| 3.1.1.8 | 0.00143 | - |
- |
Homo sapiens | 3-[6-(benzylmethylamino)hexyloxy]xanthen-9-one | |
| 3.1.1.8 | 0.00185 | - |
- |
Homo sapiens | 3-[7-[(3-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one | |
| 3.1.1.8 | 0.00191 | - |
- |
Homo sapiens | 3-[3-[(2-methoxybenzyl)methylamino]propoxy]-xanthen-9-one | |
| 3.1.1.8 | 0.00201 | - |
- |
Homo sapiens | 3-[7-[(2,3-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one | |
| 3.1.1.8 | 0.00211 | - |
- |
Homo sapiens | 3-[7-[(4-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one | |
| 3.1.1.8 | 0.00249 | - |
- |
Homo sapiens | 3-[5-(benzylmethylamino)pentyloxy]xanthen-9-one | |
| 3.1.1.8 | 0.00265 | - |
- |
Homo sapiens | 3-[4-(benzylmethylamino)butoxy]xanthen-9-one | |
| 3.1.1.8 | 0.00308 | - |
- |
Homo sapiens | 6-[7-(benzylmethylamino)heptyloxy]-2,3-dimethoxyxanthen-9-one | |
| 3.1.1.8 | 0.00833 | - |
- |
Homo sapiens | 3-[3-(benzylmethylamino)propoxy]xanthen-9-one | |
| 3.1.1.8 | 0.014 | - |
- |
Homo sapiens | 3-[7-[methyl-(2-nitrobenzyl)amino]heptyloxy]-xanthen-9-one | |
| 3.1.1.8 | 0.0165 | - |
- |
Homo sapiens | 3-[(methyl[7-[(9-oxo-9H-xanthen-3-yl)oxy]heptyl]amino)methyl]phenyl methylcarbamate | |
| 3.1.1.8 | 0.0295 | - |
- |
Homo sapiens | 3-[7-[methyl-(2-methylbenzyl)amino]-heptyloxy]-xanthen-9-one | |
| 3.1.1.8 | 0.0461 | - |
- |
Homo sapiens | 3-[7-(benzylmethylamino)heptyloxy]-6-methoxyxanthen-9-one | |
| 3.1.1.8 | 0.048 | - |
- |
Homo sapiens | xanthostigmine | |
| 3.1.1.8 | 0.0638 | - |
- |
Homo sapiens | 3-[7-[(3-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one | |
| 3.1.1.8 | 0.127 | - |
- |
Homo sapiens | 3-[7-[(4-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one | |
| 3.1.1.8 | 0.269 | - |
- |
Homo sapiens | 3-[7-[(2-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one | |
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