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Literature summary extracted from

  • Montenegro, M.F.; Moral-Naranjo, M.T.; de la Cadena, M.P.; Campoy, F.J.; Munoz-Delgado, E.; Vidal, C.J.
    Human butyrylcholinesterase components differ in aryl acylamidase activity (2008), Biol. Chem., 389, 425-432.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.8 extracellular in blood serum Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.8 Homo sapiens
-
-
-
3.5.1.13 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.5.1.13 additional information the changing ratios of amidase to esterase activities in the human sources of the protein probably arise from post-translational modifications in subunits Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.8 blood serum
-
 Homo sapiens
-
3.1.1.8 colon
-
 Homo sapiens
-
3.1.1.8 colonic cancer cell
-
 Homo sapiens
-
3.1.1.8 kidney
-
 Homo sapiens
-
3.5.1.13 colon
-
 Homo sapiens
-
3.5.1.13 gut
-
 Homo sapiens
-
3.5.1.13 kidney
-
 Homo sapiens
-
3.5.1.13 serum
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.8 0.0011
-
 BChE activity in colon cancer Homo sapiens
3.1.1.8 0.0026
-
 BChE activity in kidney Homo sapiens
3.1.1.8 0.003
-
 BChE activity in colon Homo sapiens
3.1.1.8 0.0291
-
 BChE activity in blood serum Homo sapiens
3.5.1.13 0.00002
-
 source tissue: cancerous gut Homo sapiens
3.5.1.13 0.00007
-
 source tissue: blood serum Homo sapiens
3.5.1.13 0.00018
-
 source tissue: healthy gut Homo sapiens
3.5.1.13 0.00018
-
 source tissue: kidney Homo sapiens
3.5.1.13 0.0024
-
 source tissue: cancerous gut Homo sapiens
3.5.1.13 0.0055
-
 source tissue: healthy gut Homo sapiens
3.5.1.13 0.006
-
 source tissue: blood serum Homo sapiens
3.5.1.13 0.0078
-
 source tissue: kidney Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.8 additional information the enzyme shows in addition to its esterase activity also aryl acylamidase activity, EC 3.5.1.13, hydrolyzing 2-nitroacetanilide and its trifluoro-derivative, the ratio of the two activities depends on the tissue source and oligomeric state of the enzyme, the aryl acylamidase activity is low for tetramers, but increased for monomeric enzyme, overview Homo sapiens ?
-
 ?
3.5.1.13 N-(2-nitrophenyl)-trifluoroacetamide + H2O
-
 Homo sapiens 2-nitroaniline + trifluoroacetic acid
-
 ?
3.5.1.13 o-nitroacetanilide + H2O
-
 Homo sapiens 2-nitroaniline + acetate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.8 monomer in colon and kidney Homo sapiens
3.1.1.8 tetramer
-
 Homo sapiens
3.5.1.13 More protein can polymerize, exists in monomers, dimers, tetramers. The monomeric form shows the highest aryl acylamidase activity Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.1.1.8 BChE
-
 Homo sapiens
3.1.1.8 butyrylcholinesterase
-
 Homo sapiens
3.5.1.13 AAA
-
 Homo sapiens
3.5.1.13 aryl acylamidase
-
 Homo sapiens