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Literature summary extracted from
- Biochemical properties and cellular localization of Plasmodium falciparum protein disulfide isomerase (2007), Biochimie, 89, 337-346.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 5.3.4.1 | expression of His-tagged PDI in Escherichia coli periplasmic space | Plasmodium falciparum |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.4.1 | protein DS61 | - |
Plasmodium falciparum |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 5.3.4.1 | endoplasmic reticulum | - |
Plasmodium falciparum | 5783 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.3.4.1 | Plasmodium falciparum | - |
strains 3D7 and FcB1, isozyme PDI-22 | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 5.3.4.1 | recombinant His-tagged PDI from Escherichia coli by nickel affinnity chromatography | Plasmodium falciparum |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 5.3.4.1 | additional information | PDI expression during parasite development, overview | Plasmodium falciparum | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.4.1 | insulin | bovine substrate, reduction of disulfide bonds | Plasmodium falciparum | ? | - |
? |  |
| 5.3.4.1 | additional information | the enzyme shows disulfide oxidase/isomerase, reductase, and chaperone activities, overview | Plasmodium falciparum | ? | - |
? | |
| 5.3.4.1 | rhodanese | the protein substrate is devoid of disulfide bonds, chaperone activity | Plasmodium falciparum | ? | - |
? | |
| 5.3.4.1 | RNase A | reduced and denatured substrate, oxidase/isomerase activity on the refolding of the substrate | Plasmodium falciparum | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 5.3.4.1 | monomer | predominantly, isozyme PDI-22, SDS-PAGE and gel filtration | Plasmodium falciparum |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.3.4.1 | PDI | - |
Plasmodium falciparum |
| 5.3.4.1 | protein disulfide isomerase | - |
Plasmodium falciparum |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 5.3.4.1 | 0.43 | - |
isozyme PDI-22 | Plasmodium falciparum | protein DS61 |
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