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Literature summary extracted from

  • Wang, S.; Li, H.
    Radical scavenging activity of ribonuclease inhibitor from cow placenta (2006), Biochemistry (Moscow), 71, 520-524.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.6.1.18 pharmacology radical-scavenging effects of the ribonuclease inhibitor CPRI may contribute to its function in the cell protection from peroxidative injuries unrelated to inhibition of RNases Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.18 ribonuclease inhibitor CPRI scavenger of pancreatic-type ribonucleases, chemiluminescence assay to determine radical scavenging activities toward different reactive oxygen species (ROS) including superoxide anion, hydroxyl radical, lipid-derived radicals and singlet oxygen Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.18 RNA + H2O Bos taurus
-
 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.18 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.18 placenta
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.6.1.18 additional information
-
 for assay conditions ribonuclease A solution prepared by dissolving 8 mg ribonuclease A in 4 ml 0.1 M NaHCO3 at pH 9.5 following by pre-cooling to 3°C Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.18 RNA + H2O
-
 Bos taurus 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?
4.6.1.18 RNA + H2O studies on radical scavenging activities of the ribonuclease inhibitor CPRI, a scavenger of pancreatic-type ribonucleases Bos taurus 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.18 pancreatic ribonuclease
-
 Bos taurus
4.6.1.18 ribonuclease A
-
 Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.6.1.18 9.5
-
 assay at Bos taurus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
4.6.1.18 additional information
-
 radical scavenging activities of CPRI indicated, measured by chemiluminescence, values shown, radical scavenging activities higher than those of tea polyphenols Bos taurus additional information