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Literature summary extracted from
- An in vitro comparative study on the reactivation of nerve agent-inhibited guinea pig and human acetylcholinesterases by oximes (2007), Biochemistry, 46, 11771-11779.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.7 | 2-PAM | i.e. 2-[hydroxyiminomethyl]-1-methyl-pyridinium chloride, an oxime that reactivates nerve-agent-inhibited AChE | Cavia porcellus |  |
| 3.1.1.7 | 2-PAM | i.e. 2-[hydroxyiminomethyl]-1-methyl-pyridinium chloride, an oxime that reactivates nerve-agent-inhibited AChE | Homo sapiens | |
| 3.1.1.7 | HI-6 | i.e. 1-[[[4-(aminocarbonyl)pyridinio]methoxy]methyl]-2-[(hydroxyimino)methyl]-pyridinium dimethanesulfonate, an oxime that reactivates nerve-agent-inhibited AChE | Cavia porcellus | |
| 3.1.1.7 | HI-6 | i.e. 1-[[[4-(aminocarbonyl)pyridinio]methoxy]methyl]-2-[(hydroxyimino)methyl]-pyridinium dimethanesulfonate, an oxime that reactivates nerve-agent-inhibited AChE | Homo sapiens | |
| 3.1.1.7 | HLo-7 | i.e. 1-[[[4-(aminocarbonyl)pyridinio]-methoxy]methyl]-2,4-bis-[(hydroxylimino)methyl] pyridinium dimethanesulfonate, an oxime that reactivates nerve-agent-inhibited AChE | Cavia porcellus | |
| 3.1.1.7 | HLo-7 | i.e. 1-[[[4-(aminocarbonyl)pyridinio]-methoxy]methyl]-2,4-bis-[(hydroxylimino)methyl] pyridinium dimethanesulfonate, an oxime that reactivates nerve-agent-inhibited AChE | Homo sapiens | |
| 3.1.1.7 | ICD-585 | i.e. 1-(2-hydroxyiminomethyl-1-pyridinium)-1'-(4-carboxy-aminopyridinium)-trimethylene hydrochloride, an oxime that reactivates nerve-agent-inhibited AChE | Cavia porcellus | |
| 3.1.1.7 | ICD-585 | i.e. 1-(2-hydroxyiminomethyl-1-pyridinium)-1'-(4-carboxy-aminopyridinium)-trimethylene hydrochloride, an oxime that reactivates nerve-agent-inhibited AChE | Homo sapiens | |
| 3.1.1.7 | MMB4 | i.e. 1,1'-trimethylene bis(4-hydroxyimino methyl) pyridinium dichloride, an oxime that reactivates nerve-agent-inhibited AChE | Cavia porcellus | |
| 3.1.1.7 | MMB4 | i.e. 1,1'-trimethylene bis(4-hydroxyimino methyl) pyridinium dichloride, an oxime that reactivates nerve-agent-inhibited AChE | Homo sapiens | |
| 3.1.1.7 | additional information | the reactivation of nerve agent-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, is the most important step in the treatment of nerve agent poisoning, e.g. by G and V type nerve agents, reactivation kinetics, overview | Cavia porcellus | |
| 3.1.1.7 | additional information | the reactivation of nerve agent-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, is the most important step in the treatment of nerve agent poisoning, e.g. by G and V type nerve agents, reactivation kinetics, overview | Homo sapiens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.1.1.7 | stable expression in CHO cells | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.7 | cyclosarin | reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview | Cavia porcellus | |
| 3.1.1.7 | cyclosarin | reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview | Homo sapiens | |
| 3.1.1.7 | additional information | the reactivation of nerve agent-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, is the most important step in the treatment of nerve agent poisoning, e.g. by G and V type nerve agents, reactivation kinetics, determination of the aging rate constants of nerve agent-inhibited AChE, overview | Cavia porcellus | |
| 3.1.1.7 | additional information | the reactivation of nerve agent-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, is the most important step in the treatment of nerve agent poisoning, e.g. by G and V type nerve agents, reactivation kinetics, determination of the aging rate constants of nerve agent-inhibited AChE, overview | Homo sapiens | |
| 3.1.1.7 | O-ethyl S-2-N,N-diisopropylaminoethyl methylphosphonothiolate | reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview | Cavia porcellus | |
| 3.1.1.7 | O-ethyl S-2-N,N-diisopropylaminoethyl methylphosphonothiolate | reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview | Homo sapiens | |
| 3.1.1.7 | O-isobutyl S-2-N,N-diethylaminoethyl methylphosphonothiolate | reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview | Cavia porcellus | |
| 3.1.1.7 | O-isobutyl S-2-N,N-diethylaminoethyl methylphosphonothiolate | reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview | Homo sapiens | |
| 3.1.1.7 | sarin | reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview | Cavia porcellus | |
| 3.1.1.7 | sarin | reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview | Homo sapiens | |
| 3.1.1.7 | soman | reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview | Cavia porcellus | |
| 3.1.1.7 | soman | reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview | Homo sapiens | |
| 3.1.1.7 | Tabun | reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview | Cavia porcellus | |
| 3.1.1.7 | Tabun | reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview | Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.1.7 | membrane | anchored to erythrocyte membranes | Cavia porcellus | 16020 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.7 | additional information | Cavia porcellus | the reactivation of nerve agent-inhibited acetylcholinesterase by oxime is the most important step in the treatment of nerve agent poisoning, overview | ? | - |
? | |
| 3.1.1.7 | additional information | Homo sapiens | the reactivation of nerve agent-inhibited acetylcholinesterase by oxime is the most important step in the treatment of nerve agent poisoning, overview | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.7 | Cavia porcellus | - |
- |
- |
| 3.1.1.7 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.1.7 | native enzyme released from erythrocyte membranes anchor by phosphatidylinositol-specific phospholipase C, followed by affinity chromatography on a procainamide resin, and anion exchange chromatography | Cavia porcellus |
| 3.1.1.7 | recombinant enzyme from stably expressing CHO cells by affinity chromatography on a procainamide resin, to homogeneity | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.1.7 | erythrocyte | - |
Cavia porcellus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.7 | additional information | - |
- |
Cavia porcellus |
| 3.1.1.7 | additional information | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.7 | acetylthiocholine + H2O | - |
Cavia porcellus | thiocholine + acetate | - |
? | |
| 3.1.1.7 | acetylthiocholine + H2O | - |
Homo sapiens | thiocholine + acetate | - |
? | |
| 3.1.1.7 | additional information | the reactivation of nerve agent-inhibited acetylcholinesterase by oxime is the most important step in the treatment of nerve agent poisoning, overview | Cavia porcellus | ? | - |
? | |
| 3.1.1.7 | additional information | the reactivation of nerve agent-inhibited acetylcholinesterase by oxime is the most important step in the treatment of nerve agent poisoning, overview | Homo sapiens | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.1.1.7 | dimer | - |
Cavia porcellus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.1.7 | AChE | - |
Cavia porcellus |
| 3.1.1.7 | AChE | - |
Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.7 | 25 | - |
assay at | Cavia porcellus |
| 3.1.1.7 | 25 | - |
assay at | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.7 | 8 | - |
assay at | Cavia porcellus |
| 3.1.1.7 | 8 | - |
assay at | Homo sapiens |
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