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Literature summary extracted from

  • Okai, M.; Kudo, N.; Lee, W.C.; Kamo, M.; Nagata, K.; Tanokura, M.
    Crystal structures of the short-chain flavin reductase HpaC from Sulfolobus tokodaii strain 7 in its three states: NAD(P)(+)-free, NAD(+)-bound, and NADP(+)-bound (2006), Biochemistry, 45, 5103-5110.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.5.1.30 in NAD(P)(+)-free, NAD(+)-bound, and NADP(+)-bound states. The nicotinamide of NAD+ stacks the isoalloxazine ring of FMN so that NADH can directly transfer hydride. The bound NADP+ also has a compact conformation but is bound in a reverse direction, which is not suitable for hydride transfer Sulfurisphaera tokodaii

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.30 Sulfurisphaera tokodaii
-
 stain 7
-
1.5.1.30 Sulfurisphaera tokodaii 7
-
 stain 7
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.5.1.30 reduced riboflavin + NADP+ = riboflavin + NADPH + H+ the nicotinamide of NAD+ stacks the isoalloxazine ring of FMN so that NADH can directly transfer hydride. The bound NADP+ also has a compact conformation but is bound in a reverse direction, which is not suitable for hydride transfer Sulfurisphaera tokodaii
a

Synonyms

EC Number Synonyms Comment Organism
1.5.1.30 HpaC
-
 Sulfurisphaera tokodaii

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.30 FMN one molecule per monomer of enzyme. FMN is preferred over FAD Sulfurisphaera tokodaii
1.5.1.30 NADP+
-
 Sulfurisphaera tokodaii