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Literature summary extracted from

  • Li, T.; Hawkes, C.; Qureshi, H.Y.; Kar, S.; Paudel, H.K.
    Cyclin-dependent protein kinase 5 primes microtubule-associated protein tau site-specifically for glycogen synthase kinase 3beta (2006), Biochemistry, 45, 3134-3145.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.22 p25 primes tau protein for GSK3beta in vivo Homo sapiens
2.7.11.22 p35 primes tau protein for GSK3beta in vivo Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.22 Cdk5 cDNA subcloned into pcDNA 3.1/HisA vector, HEK-293 cells cotransfected with tau protein, GSK3beta, and Cdk5 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.22 Olomoucine Cdk5 inhibitor, tau protein phosphorylation at S202, S235, and S404 is inhibited to a basal level Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.22 microtubule
-
 Bos taurus 5874
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.11.22 25000
-
 immunoblot analysis Bos taurus
2.7.11.22 450000
-
 complex of Cdk5, GSK3beta, and tau protein, gel filtration Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.22 ATP + tau protein Homo sapiens Cdk5 phosphorylates at S202, S235, and S404, phosphorylation at S235 primes it for phosphorylation of T231 by GSK3beta, phosphorylating tau protein at S404 primes tau protein for a sequential phosphorylation of S400 and S396 by GSK3beta ADP + phosphorylated tau protein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.22 Bos taurus
-
-
-
2.7.11.22 Homo sapiens
-
-
-
2.7.11.22 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.22 brain
-
 Bos taurus
-
2.7.11.22 brain is colocalized with tau protein and GSK3beta in brain cortex Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.22 ATP + tau protein
-
 Homo sapiens ADP + phosphorylated tau protein
-
 ?
2.7.11.22 ATP + tau protein
-
 Rattus norvegicus ADP + phosphorylated tau protein
-
 ?
2.7.11.22 ATP + tau protein
-
 Bos taurus ADP + phosphorylated tau protein
-
 ?
2.7.11.22 ATP + tau protein Cdk5 phosphorylates at S202, S235, and S404, phosphorylation at S235 primes it for phosphorylation of T231 by GSK3beta, phosphorylating tau protein at S404 primes tau protein for a sequential phosphorylation of S400 and S396 by GSK3beta Homo sapiens ADP + phosphorylated tau protein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.22 Cdk5
-
 Homo sapiens
2.7.11.22 Cdk5
-
 Rattus norvegicus
2.7.11.22 Cdk5
-
 Bos taurus
2.7.11.22 cyclin-dependent protein kinase 5
-
 Homo sapiens
2.7.11.22 cyclin-dependent protein kinase 5
-
 Rattus norvegicus
2.7.11.22 cyclin-dependent protein kinase 5
-
 Bos taurus