Literature summary extracted from

Olivares-Illana, V.; Perez-Montfort, R.; Lopez-Calahorra, F.; Costas, M.; Rodriguez-Romero, A.; Tuena de Gomez-Puyou, M.; Gomez Puyou, A.
Structural differences in triosephosphate isomerase from different species and discovery of a multitrypanosomatid inhibitor (2006), Biochemistry, 45, 2556-2560.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
5.3.1.1	2,2'-methylenebis(1,3-benzothiazole)	irreversible inactivation	Leishmania mexicana
5.3.1.1	2,2'-methylenebis(1,3-benzothiazole)	irreversible inactivation	Trypanosoma brucei
5.3.1.1	2,2'-methylenebis(1,3-benzothiazole)	40% inactivation at 0.05 mM, irreversible	Trypanosoma cruzi
5.3.1.1	6,6'-bi-1,3-benzothiazole-2,2'-diamine	irreversible inactivation. Not inhibitory on human, yeast, chicken, Plasmodium falciparum, and Entamoeba histolytica enzyme	Leishmania mexicana
5.3.1.1	6,6'-bi-1,3-benzothiazole-2,2'-diamine	irreversible inactivation. Not inhibitory on human, yeast, chicken, Plasmodium falciparum, and Entamoeba histolytica enzyme	Trypanosoma brucei
5.3.1.1	6,6'-bi-1,3-benzothiazole-2,2'-diamine	91% inactivation at 0.05 mM, irreversible. Not inhibitory on human, yeast, chicken, Plasmodium falciparum, and Entamoeba histolytica enzyme	Trypanosoma cruzi

Organism

EC Number	Organism	UniProt	Comment	Textmining
5.3.1.1	Leishmania mexicana	-	-	-
5.3.1.1	Trypanosoma brucei	-	-	-
5.3.1.1	Trypanosoma cruzi	-	-	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)