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Literature summary extracted from

  • Singh, V.; Shi, W.; Almo, S.C.; Evans, G.B.; Furneaux, R.H.; Tyler, P.C.; Painter, G.F.; Lenz, D.H.; Mee, S.; Zheng, R.; Schramm, V.L.
    Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae (2006), Biochemistry, 45, 12929-12941.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.2.2.9 expression in Escherichia coli Escherichia coli
3.2.2.9 expression in Escherichia coli Streptococcus pneumoniae
3.2.2.16 expression in Escherichia coli Escherichia coli
3.2.2.16 expression in Escherichia coli Streptococcus pneumoniae

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.2.2.9 enzyme in complex with transition state analogue methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A. Enzyme forms a dimer with the methylthio group in a flexible hydrophobic pocket Escherichia coli
3.2.2.9 enzyme in complex with transition state analogue methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A. Enzyme forms a dimer with the methylthio group in a flexible hydrophobic pocket Streptococcus pneumoniae
3.2.2.16 enzyme in complex with transition state analogue methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A. Enzyme forms a dimer with the methylthio group in a flexible hydrophobic pocket Escherichia coli
3.2.2.16 enzyme in complex with transition state analogue methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A. Enzyme forms a dimer with the methylthio group in a flexible hydrophobic pocket Streptococcus pneumoniae

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.2.9 4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
Escherichia coli
3.2.2.9 4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
Streptococcus pneumoniae
3.2.2.9 ethylthio-immucillin-A
-
Escherichia coli
3.2.2.9 ethylthio-immucillin-A
-
Streptococcus pneumoniae
3.2.2.9 methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
Escherichia coli
3.2.2.9 methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
Streptococcus pneumoniae
3.2.2.9 methylthio-immucillin-A weak Escherichia coli
3.2.2.9 methylthio-immucillin-A weak Streptococcus pneumoniae
3.2.2.9 p-tolylthio-immucillin-A
-
Escherichia coli
3.2.2.9 p-tolylthio-immucillin-A
-
Streptococcus pneumoniae
3.2.2.9 phenylthio-immucillin-A
-
Escherichia coli
3.2.2.9 phenylthio-immucillin-A
-
Streptococcus pneumoniae
3.2.2.16 4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
Escherichia coli
3.2.2.16 4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
Streptococcus pneumoniae
3.2.2.16 ethylthio-immucillin-A
-
Escherichia coli
3.2.2.16 ethylthio-immucillin-A
-
Streptococcus pneumoniae
3.2.2.16 methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
Escherichia coli
3.2.2.16 methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
Streptococcus pneumoniae
3.2.2.16 methylthio-immucillin-A weak Escherichia coli
3.2.2.16 methylthio-immucillin-A weak Streptococcus pneumoniae
3.2.2.16 p-tolylthio-immucillin-A
-
Escherichia coli
3.2.2.16 p-tolylthio-immucillin-A
-
Streptococcus pneumoniae
3.2.2.16 phenylthio-immucillin-A
-
Escherichia coli
3.2.2.16 phenylthio-immucillin-A
-
Streptococcus pneumoniae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.2.2.9 0.013
-
S-adenosyl-L-homocysteine pH 7.5, 25°C Streptococcus pneumoniae
3.2.2.9 0.023
-
5'-methylthioadenosine pH 7.5, 25°C Streptococcus pneumoniae
3.2.2.9 0.43
-
5'-methylthioadenosine pH 7.5, 25°C Escherichia coli
3.2.2.9 1.3
-
S-adenosyl-L-homocysteine pH 7.5, 25°C Escherichia coli
3.2.2.16 0.013
-
S-adenosyl-L-homocysteine pH 7.5, 25°C Streptococcus pneumoniae
3.2.2.16 0.023
-
5'-methylthioadenosine pH 7.5, 25°C Streptococcus pneumoniae
3.2.2.16 0.43
-
5'-methylthioadenosine pH 7.5, 25°C Escherichia coli
3.2.2.16 1.3
-
S-adenosyl-L-homocysteine pH 7.5, 25°C Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.9 Escherichia coli
-
bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
-
3.2.2.9 Streptococcus pneumoniae
-
bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
-
3.2.2.16 Escherichia coli
-
bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
-
3.2.2.16 Streptococcus pneumoniae Q8DQ16 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.2.9 5'-methylthioadenosine + H2O
-
Escherichia coli 5-methylthio-D-ribose + adenine
-
?
3.2.2.9 5'-methylthioadenosine + H2O
-
Streptococcus pneumoniae 5-methylthio-D-ribose + adenine
-
?
3.2.2.9 additional information no substrate: adenosine, inosine Escherichia coli ?
-
?
3.2.2.9 additional information no substrate: adenosine, inosine Streptococcus pneumoniae ?
-
?
3.2.2.9 S-adenosyl-L-homocysteine + H2O
-
Escherichia coli adenine + S-ribosyl-L-homocysteine
-
?
3.2.2.9 S-adenosyl-L-homocysteine + H2O
-
Streptococcus pneumoniae adenine + S-ribosyl-L-homocysteine
-
?
3.2.2.16 5'-methylthioadenosine + H2O
-
Escherichia coli 5-methylthio-D-ribose + adenine
-
?
3.2.2.16 5'-methylthioadenosine + H2O
-
Streptococcus pneumoniae 5-methylthio-D-ribose + adenine
-
?
3.2.2.16 S-adenosyl-L-homocysteine + H2O
-
Escherichia coli adenine + S-ribosyl-L-homocysteine
-
?
3.2.2.16 S-adenosyl-L-homocysteine + H2O
-
Streptococcus pneumoniae adenine + S-ribosyl-L-homocysteine
-
?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.2.2.9 0.25
-
5'-methylthioadenosine pH 7.5, 25°C Streptococcus pneumoniae
3.2.2.9 0.37
-
S-adenosyl-L-homocysteine pH 7.5, 25°C Streptococcus pneumoniae
3.2.2.9 2.1
-
S-adenosyl-L-homocysteine pH 7.5, 25°C Escherichia coli
3.2.2.9 4
-
5'-methylthioadenosine pH 7.5, 25°C Escherichia coli
3.2.2.16 0.25
-
5'-methylthioadenosine pH 7.5, 25°C Streptococcus pneumoniae
3.2.2.16 0.37
-
S-adenosyl-L-homocysteine pH 7.5, 25°C Streptococcus pneumoniae
3.2.2.16 2.1
-
S-adenosyl-L-homocysteine pH 7.5, 25°C Escherichia coli
3.2.2.16 4
-
5'-methylthioadenosine pH 7.5, 25°C Escherichia coli

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.2.2.9 0.00000036
-
4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A pH 7.5, 25°C Escherichia coli
3.2.2.9 0.00000036
-
4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A pH 7.5, 25°C Streptococcus pneumoniae
3.2.2.9 0.000024
-
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A pH 7.5, 25°C Escherichia coli
3.2.2.9 0.000024
-
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A pH 7.5, 25°C Streptococcus pneumoniae
3.2.2.9 0.00004
-
ethylthio-immucillin-A pH 7.5, 25°C Escherichia coli
3.2.2.9 0.00004
-
ethylthio-immucillin-A pH 7.5, 25°C Streptococcus pneumoniae
3.2.2.9 0.00006
-
p-tolylthio-immucillin-A pH 7.5, 25°C Escherichia coli
3.2.2.9 0.00006
-
p-tolylthio-immucillin-A pH 7.5, 25°C Streptococcus pneumoniae
3.2.2.9 0.000335
-
phenylthio-immucillin-A pH 7.5, 25°C Escherichia coli
3.2.2.9 0.000335
-
phenylthio-immucillin-A pH 7.5, 25°C Streptococcus pneumoniae
3.2.2.9 0.001
-
methylthio-immucillin-A pH 7.5, 25°C Escherichia coli
3.2.2.9 0.001
-
methylthio-immucillin-A pH 7.5, 25°C Streptococcus pneumoniae
3.2.2.16 0.00000036
-
4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A pH 7.5, 25°C Escherichia coli
3.2.2.16 0.00000036
-
4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A pH 7.5, 25°C Streptococcus pneumoniae
3.2.2.16 0.000024
-
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A pH 7.5, 25°C Escherichia coli
3.2.2.16 0.000024
-
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A pH 7.5, 25°C Streptococcus pneumoniae
3.2.2.16 0.00004
-
ethylthio-immucillin-A pH 7.5, 25°C Escherichia coli
3.2.2.16 0.00004
-
ethylthio-immucillin-A pH 7.5, 25°C Streptococcus pneumoniae
3.2.2.16 0.00006
-
p-tolylthio-immucillin-A pH 7.5, 25°C Escherichia coli
3.2.2.16 0.00006
-
p-tolylthio-immucillin-A pH 7.5, 25°C Streptococcus pneumoniae
3.2.2.16 0.000335
-
phenylthio-immucillin-A pH 7.5, 25°C Escherichia coli
3.2.2.16 0.000335
-
phenylthio-immucillin-A pH 7.5, 25°C Streptococcus pneumoniae
3.2.2.16 0.001
-
methylthio-immucillin-A pH 7.5, 25°C Escherichia coli
3.2.2.16 0.001
-
methylthio-immucillin-A pH 7.5, 25°C Streptococcus pneumoniae