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Literature summary extracted from

  • Arden, C.; Hampson, L.J.; Huang, G.C.; Shaw, J.A.; Aldibbiat, A.; Holliman, G.; Manas, D.; Khan, S.; Lange, A.J.; Agius, L.
    A role for PFK-2/FBPase-2 as distinct from fructose 2,6-bisphosphate in regulation of insulin secretion in pancreatic beta-cells (2007), Biochem. J., 411, 41-51.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.3.46 molecular biology overexpression alone has negligible effects on insulin secretion, only in combination with 6-phosphofructo-2-kinase, partial down-regulation of endogenous PFKFB2 and PFKFB3 in INS1 cells by siRNA decreased PFK-2/FBPase-2 protein, fructose 2,6-bisphosphate content, glucokinase activity and glucose-induced insulin secretion Mus musculus
3.1.3.46 molecular biology overexpression alone has negligible effects on insulin secretion, only in combination with 6-phosphofructo-2-kinase, partial down-regulation of endogenous PFKFB2 and PFKFB3 in INS1 cells by siRNA decreased PFK-2/FBPase-2 protein, fructose 2,6-bisphosphate content, glucokinase activity and glucose-induced insulin secretion Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.46 expression in hepatocytes by incubation for 2h with increasing titres of adenoviral vectors Rattus norvegicus
3.1.3.46 expression in MIN-6 cell by incubation for 2h with increasing titres of adenoviral vectors Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.46 additional information Mus musculus the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting ?
-
 ?
3.1.3.46 additional information Rattus norvegicus the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting ?
-
 ?
3.1.3.46 additional information Mus musculus C57/BL6 the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting ?
-
 ?
3.1.3.46 additional information Rattus norvegicus Wistar the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.46 Homo sapiens
-
-
-
3.1.3.46 Mus musculus
-
 C57/BL6
-
3.1.3.46 Mus musculus C57/BL6
-
 C57/BL6
-
3.1.3.46 Rattus norvegicus
-
 Wistar
-
3.1.3.46 Rattus norvegicus Wistar
-
 Wistar
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.46 hepatocyte
-
 Rattus norvegicus
-
3.1.3.46 INS-1 cell
-
 Rattus norvegicus
-
3.1.3.46 MIN-6 cell
-
 Mus musculus
-
3.1.3.46 additional information PFKFB2 and PFKFB3 mRNA is expressed in human islet cells Homo sapiens
-
3.1.3.46 pancreatic islet
-
 Mus musculus
-
3.1.3.46 pancreatic islet
-
 Homo sapiens
-
3.1.3.46 pancreatic islet
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O
-
 Mus musculus D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O
-
 Homo sapiens D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O
-
 Rattus norvegicus D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O
-
 Mus musculus C57/BL6 D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O
-
 Rattus norvegicus Wistar D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 additional information the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting Mus musculus ?
-
 ?
3.1.3.46 additional information the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting Rattus norvegicus ?
-
 ?
3.1.3.46 additional information the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting Mus musculus C57/BL6 ?
-
 ?
3.1.3.46 additional information the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting Rattus norvegicus Wistar ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.46 6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
-
 Mus musculus
3.1.3.46 6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
-
 Homo sapiens
3.1.3.46 6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
-
 Rattus norvegicus
3.1.3.46 FBPase-2
-
 Mus musculus
3.1.3.46 FBPase-2
-
 Homo sapiens
3.1.3.46 FBPase-2
-
 Rattus norvegicus
3.1.3.46 PFKFB1
-
 Mus musculus
3.1.3.46 PFKFB1
-
 Homo sapiens
3.1.3.46 PFKFB1
-
 Rattus norvegicus
3.1.3.46 PFKFB2
-
 Mus musculus
3.1.3.46 PFKFB2
-
 Homo sapiens
3.1.3.46 PFKFB2
-
 Rattus norvegicus
3.1.3.46 PFKFB3
-
 Mus musculus
3.1.3.46 PFKFB3
-
 Homo sapiens
3.1.3.46 PFKFB3
-
 Rattus norvegicus