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Literature summary extracted from

  • Pearce, F.G.; Perugini, M.A.; McKerchar, H.J.; Gerrard, J.A.
    Dihydrodipicolinate synthase from Thermotoga maritima (2006), Biochem. J., 400, 359-366.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.3.3.7
-
 Thermotoga maritima

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.3.3.7 the X-ray crystal structure is described Thermotoga maritima

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.3.3.7 additional information not inhibited by (S)-lysine, suggesting that feedback control of the lysine biosynthetic pathway evolves later in the bacterial lineage Thermotoga maritima

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.3.3.7 33800
-
 4 * 33800, calculated from sequence Thermotoga maritima
4.3.3.7 133000
-
 sedimentation equilibrium analysis Thermotoga maritima

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.3.3.7 (S)-aspartate 4-semialdehyde + pyruvate Thermotoga maritima catalyses the branch point in lysine biosynthesis dihydrodipicolinate + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.3.3.7 Thermotoga maritima Q9X1K9
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.3.3.7
-
 Thermotoga maritima

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.3.7 (S)-aspartate 4-semialdehyde + pyruvate catalyses the branch point in lysine biosynthesis Thermotoga maritima dihydrodipicolinate + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
4.3.3.7 tetramer 4 * 33800, calculated from sequence Thermotoga maritima

Synonyms

EC Number Synonyms Comment Organism
4.3.3.7 DHDPS
-
 Thermotoga maritima

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
4.3.3.7 90
-
 7 h, 40% loss of activity. When the enzyme is incubated at 90°C in 8M urea, 60% of the activity is lost after 90 min Thermotoga maritima