Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Beltran, C.; Vacquier, V.D.; Moy, G.; Chen, Y.; Buck, J.; Levin, L.R.; Darszon, A.
    Particulate and soluble adenylyl cyclases participate in the sperm acrosome reaction (2007), Biochem. Biophys. Res. Commun., 358, 1128-1135.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.1 bicarbonate 50 mM stimulate sAC activity 2fold Strongylocentrotus purpuratus
4.6.1.1 forskolin stimulates tmAC activity 1.6fold Strongylocentrotus purpuratus
4.6.1.1 NaF stimulates tmAC activity 2.9fold Strongylocentrotus purpuratus

Application

EC Number Application Comment Organism
4.6.1.1 additional information both sAC and tmACs participate in the sperm acrosome reaction and sperm motility Strongylocentrotus purpuratus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.1 2',5'-dideoxyadenosine inhibits forskolin induced tmAC stimulation at 0.15 mM Strongylocentrotus purpuratus
4.6.1.1 2-hydroxyestradiol selective sAC inhibitor, inhibits the jelly induced acrosome reaction by 30% as well as the increase in cAMP levels by 42% Strongylocentrotus purpuratus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.6.1.1 membrane present in the head, acrosomal and mitochondrial area and in flagellar membranes of sperm Strongylocentrotus purpuratus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.6.1.1 Mn2+
-
 Strongylocentrotus purpuratus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.6.1.1 75000
-
 degraded sAC, Western blot analysis Strongylocentrotus purpuratus
4.6.1.1 190000
-
 Western blot analysis Strongylocentrotus purpuratus

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.1 Strongylocentrotus purpuratus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.6.1.1 partially purified Strongylocentrotus purpuratus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.1 additional information flagellum Strongylocentrotus purpuratus
-
4.6.1.1 sperm both tmAC and sAC present, presence of more than one tmAC isoform in sea urchin sperm Strongylocentrotus purpuratus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.1 ATP
-
 Strongylocentrotus purpuratus 3',5'-cAMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.1 particulate adenylyl cyclase
-
 Strongylocentrotus purpuratus
4.6.1.1 sAC
-
 Strongylocentrotus purpuratus
4.6.1.1 soluble adenylyl cyclase
-
 Strongylocentrotus purpuratus
4.6.1.1 tmAC
-
 Strongylocentrotus purpuratus
4.6.1.1 transmembrane adenylyl cyclase
-
 Strongylocentrotus purpuratus