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Literature summary extracted from

  • Schallreuter, K.U.; Gibbons, N.C.; Elwary, S.M.; Parkin, S.M.; Wood, J.M.
    Calcium-activated butyrylcholinesterase in human skin protects acetylcholinesterase against suicide inhibition by neurotoxic organophosphates (2007), Biochem. Biophys. Res. Commun., 355, 1069-1074.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 O-ethyl-O-(4-nitrophenyl)-phenylphosphonothioate
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.1.7 additional information AchE is not affected by Ca2+ Homo sapiens
3.1.1.8 Ca2+ activates 9fold at 0.5 mM with substrate O-ethyl-O-(4-nitrophenyl)-phenylphosphonothioate via a specific EF-hand calcium binding site, molecular modelling of Ca2+ binding to EF-hands, disruption by H2O2-mediated oxidation Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.7 additional information Homo sapiens calcium-activated BuchE, EC 3.1.1.8, acts as a major protective mechanism against suicide inhibition of AchE by organophosphates in this non-neuronal tissue, overview ?
-
 ?
3.1.1.8 butyrylthiocholine + H2O Homo sapiens
-
 thiocholine + butyrate
-
 ?
3.1.1.8 additional information Homo sapiens calcium-activated butyrylcholinesterase as a major protective mechanism against suicide inhibition of acetylcholinesterase by organophosphates in this non-neuronal tissue ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Homo sapiens
-
-
-
3.1.1.8 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.7 skin
-
 Homo sapiens
-
3.1.1.8 skin
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.7 acetylthiocholine + H2O
-
 Homo sapiens thiocholine + acetate
-
 ?
3.1.1.7 additional information calcium-activated BuchE, EC 3.1.1.8, acts as a major protective mechanism against suicide inhibition of AchE by organophosphates in this non-neuronal tissue, overview Homo sapiens ?
-
 ?
3.1.1.8 butyrylthiocholine + H2O
-
 Homo sapiens thiocholine + butyrate
-
 ?
3.1.1.8 additional information calcium-activated butyrylcholinesterase as a major protective mechanism against suicide inhibition of acetylcholinesterase by organophosphates in this non-neuronal tissue Homo sapiens ?
-
 ?
3.1.1.8 O-ethyl-O-(4-nitrophenyl)-phenylphosphonothioate + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.7 AChE
-
 Homo sapiens
3.1.1.8 BuChE
-
 Homo sapiens
3.1.1.8 calcium-activated butyrylcholinesterase
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.7 7.4
-
 assay at Homo sapiens
3.1.1.8 7.4
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.1.7 0.045
-
 O-ethyl-O-(4-nitrophenyl)-phenylphosphonothioate pH 7.4 Homo sapiens